节点文献
有丝分裂阻滞缺陷基因异常在肿瘤中的研究进展
Research progress of mitotic arrest deficient gene abnormalities in tumor
【摘要】 纺锤体组装检验点(spindle assembly checkpoint,SAC)是机体有丝分裂的重要监控机制,能够监控着丝点与微管之间的连接,确保染色体正确分离。有丝分裂阻滞缺陷家族蛋白(Mitotic arrest deficient protein,Mad)作为SAC的重要组成部分,其主要在正常有丝分裂过程中发挥作用。Mad家族基因突变或蛋白表达异常可能导致染色体异常分离,在促使肿瘤发生、预示肿瘤预后不良、化疗药物耐药等方面都起到一定作用。
【Abstract】 The spindle assembly checkpoint(SAC) is an important monitoring mechanism to monitor the connection between centromeres and microtubules and to ensure proper chromosome separation in human.Mitotic arrest defective protein(Mad) family,as an important part of SAC,plays a crucial role in the process of mitosis.Mutations or altered expressions of Mad may lead to abnormal separations of chromosomes and play a partial role in tumorigenesis,poor prognosis and chemotherapy drug resistance.
【关键词】 纺锤体组装检验点;
有丝分裂阻滞缺陷基因;
肿瘤;
化疗;
【Key words】 Spindle assembly checkpoint(SAC); Mitotic arrest defective(Mad); Cancer; Chemotherapy;
【Key words】 Spindle assembly checkpoint(SAC); Mitotic arrest defective(Mad); Cancer; Chemotherapy;
- 【文献出处】 实用肿瘤学杂志 ,Practical Oncology Journal , 编辑部邮箱 ,2014年02期
- 【分类号】R730.2