【摘要】 目的 探讨RECK蛋白表达与乳腺癌患者预后的关系。方法 应用免疫组织化学染色法检测148例乳腺癌标本中RECK蛋白的表达,分析RECK表达与乳腺癌临床病理因素及预后的关系。结果RECK蛋白阴性乳腺癌患者无病生存时间及5年总生存时间显著差于RECK阳性者。腋下淋巴结阴性乳腺癌患者,RECK阴性患者与阳性患者比较其预后显著不良。Cox多因素分析显示RECK阴性是乳腺癌预后不良的独立危险因素。结论 对于乳腺癌患者,RECK蛋白表达缺失提示预后不良,RECK蛋白可成为判断乳腺癌预后的重要指标之一。更多还原

【Abstract】 Objecive To explore the significance of RECK expression in breast cancer.Methods Immunohistochemical staining was used to analyze RECK expression levels in patients with breast cancer.We compared these data with the clinicopathological features of these patients.Results Breast cancer patients with negative RECK expression had significantly lower DFS and 5- year survival rates than patients with positive RECK expression.In addition,for node-negative breast cancer,negative RECK expression indicated markedly unfavorable survival rate than positive arm.Multivariate analysis further confirmed that RECK expression was an independent prognostic factor for patients with breast cancer.Conclusion The loss of RECK expression indicates unfavorable survival rate for patients with breast cancer.RECK expression is a new,important risk factor for recurrence in breast cancer.更多还原