【摘要】 目的:分析半胱氨酸蛋白酶8(CASP 8)基因-652 6N I/D多态性与2型糖尿病(T2DM)易感性的关系。方法:采用PCR-RFLP技术结合DNA测序检测414例正常人和410例2型糖尿患者CASP 8基因-652 6N I/D的多态性。结果:对照组和糖尿病组I/I、I/D和D/D的基因型频率分别为56.5%、38.9%、4.6%和58.0%、32.9%、9.0%,差异有统计学意义(P<0.05)。D/D基因型发生T2DM的风险为I/I基因型的1.916倍(95%CI=1.199~3.054,P<0.05)。D/D基因型的空腹血糖高于I/D和I/I基因型(P<0.05)。结论:CASP 8基因-652 6N I/D多态性与2型糖尿病的发生相关。更多还原

【Abstract】 Objective To investigate the association of cysteine aspartic acid specific protease 8(CASP 8)gene-652 6N Insertion / Deletion polymorphisms and susceptibility of type 2 diabetes mellitus(T2DM). Methods CASP 8 gene-652 6N I / D polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing in 414 controls and 410 patients with T2 DM. Results I / I, I / D and D / D genotype frequency were 56.5%, 38.9%, 4.6% in controls and 58.0%, 32.9%, 9.0% in T2 DM group respectively(P < 0.05). The risk in D / D genotype people was 1.916 times than I / I genotype(adjusted OR = 1.916, 95%CI =1.199 ~ 3.054, P < 0.05). The fasting blood sugar of D / D genotype people was significantly higher than that of I / D and I / I genotype people(P < 0.05). Conclusions CASP 8 gene-652 6N I / D polymorphisms are associated with T2 DM outbreak.更多还原