【摘要】 目的:探讨血管内皮生长因子(VEGF)和内皮抑素(ES)与2型糖尿病肾病的关系。方法:采用ELISA法分别检测80例2型糖尿病患者(30例无肾病、20例有微量蛋白尿、30例有大量蛋白尿)的血浆VEGF和ES水平,并进行分析。结果:(1)大量蛋白尿组血浆VEGF和ES水平均高于无肾病组和微量蛋白尿组(均P<0.05);微量蛋白尿组血浆VEGF和ES水平高于无肾病组(均P<0.05)。(2)血浆VEGF和ES水平均与尿微量白蛋白(mAlb)呈正相关(r=0.226,P<0.01;r=0.491,P<0.01),均与估计的肾小球滤过率(eGFR)呈负相关(r=-0.237,P<0.05;r=-0.620,P<0.01)。(3)无肾病组和微量蛋白尿组血浆VEGF水平均与ES呈正相关(r1=0.633,P1<0.01;r2=0.532,P2<0.05),而大量蛋白尿组血浆VEGF与ES不相关(r3=0.175,P3>0.05)。结论:血浆中VEGF和ES水平在2型糖尿病肾病不同临床分期有中不同程度的增高,并与mAlb、eGFR密切相关,且VEGF和ES的平衡失调可能加速糖尿病肾病的进展。更多还原

【Abstract】 Objective To investigate the possible association between vascular endothelial growth factor(VEGF), endostatin(ES) and type 2 diabetic nephropathy. Methods The level of serum VEGF and ES were measured by ELISA in eighty type 2 diabetic patients including thirty subjects without diabetic nephropathy, twenty with microalbuminuria and thirty with macroalbuminuria, and the correlation was analyzed. Results The level of serum VEGF and ES in patients with macroalbuminuria were both significantly higher than that of patients with and without microalbuminuria(P < 0.05). The level of serum VEGF and ES in patients with microalbuminuria were significantly higher than that of patients without diabetic nephropathy(P < 0.05). Both VEGF and ES level were positively correlated with the level of microalbuminuria(mAlb)(r = 0.226, P < 0.01; r = 0.491, P < 0.01), and negatively correlated with the level of estimated glomerular filtration rate(eGFR)(r =-0.237, P < 0.05; r =-0.620,P < 0.01). There was a significantly positive correlation between VEGF and ES in patients with microalbuminuria and macroalbuminuria(r1= 0.633, P1< 0.01; r2= 0.532, P2< 0.05). However, there was no correlation between VEGF and ES in patients without diabetic nephropathy(r3= 0.175, P3> 0.05). Conclusion The levels of VEGF and ES in type 2 diabetic nephropathy had varying degree of increasing in different diabetic nephropathy stage, and closely related to mAlb and eGFR. Disequilibrium of VEGF and ES may speed up the progression of diabetic nephropathy.更多还原