【摘要】 目的探讨原发性肝细胞癌患者中乙型肝炎病毒标志物和血清生化指标的分布状况及其与原发性肝细胞癌的关系,为原发性肝细胞癌的防治提供依据。方法测定原发性肝癌患者血清HBsAg、HBeAg、HBeAb、HBcAb等病毒标志及血清天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、白蛋白(ALB)、总胆红素(TBIL)等生化指标,以病毒标志的不同感染模式作为阳性分组依据,并与对照组比较,分析血清生化指标的分布状况及其与原发性肝细胞癌的关系。结果 217例原发性肝细胞癌患者中HBsAg阳性者165例(76.0%),HBsAg及HBeAg双阳性者44例(20.3%),"大三阳"者为55例(25.3%),"小三阳"者为87例(40.1%);在"大三阳"、"小三阳"感染组与对照组的比较中AST和ALT差异有统计学意义(P<0.001)。结论乙型肝炎病毒的感染会引起原发性肝细胞癌患者肝脏炎症损害,应同等重视"大三阳"与"小三阳"患者的抗病毒治疗,以利于原发性肝细胞癌的防治。更多还原

【Abstract】 Objective To explore the distribution of hepatitis B virus markers and serum biochemical indexes in patients with primary hepatocellular carcinoma( PHC) and the relationship between the above- mentioned markers,indexes and PHC,and to provide evidence for prevention and control of PHC. Methods HBV markers( HBsAg,HBeAg,HBeAb and HBcAb) and serum biochemical indexes( AST,ALT,ALB and TBIL) of PHC patients were detected. HBV- positive patients were subgrouped according to different infection modes of HBV markers,and then a comparison was conducted between the subgroups and control group. The distribution of serum biochemical indexes and the relationship between the indexes and PHC were analyzed. Results Among 217 patients with PHC,165( 76. 0%) were HBsAg positive,44( 20. 3%) HBsAg + HBeAg positive,55( 25. 3%) HBsAg + HBeAg + HBcAb positive and 87( 40. 1%) HBsAg + HBeAb + HBcAb positive. The serum levels of AST and ALT were higher in HBsAg + HBeAg + HBcAb positive group and HBsAg + HBeAb + HBcAb positive group than in the control group,with statistically significant difference( P < 0. 001). Conclusions The infection of hepatitis B virus may cause damage and inflammation in livers of patients with PHC. Antiviral treatment should be implemented equally in patients with HBsAg + HBeAg + HBcAb positive or HBsAg + HBeAb + HBcAb positive so as to facilitate PHC prevention and therapy.更多还原