【摘要】 目的:探讨轮状病毒(rotavirus,RV)肠炎伴良性婴幼儿惊厥的临床特点,并评价其预后。方法:回顾性分析2008年6月至2012年10月门诊及住院的RV肠炎伴良性婴幼儿惊厥患儿的临床表现、实验室检查和治疗效果并进行随访。结果:22例患儿中男14例,女8例,发病年龄6~23个月,高发年龄12~18个月,占40.90%。所有患儿均表现为全身强直–阵挛性发作,缓解后神志恢复迅速,无进行性意识障碍。所有病例均在病程72 h内发生惊厥,发作1次20例,发作2次2例,持续时间均小于5 min,对症治疗后迅速缓解。发作间期2例患儿脑电图轻度异常,表现为背景电活动变慢,均未见痫样波发放,恢复期转为正常。所有患儿头颅CT或头颅MRI,血电解质、血糖及脑脊液检查均正常。惊厥停止后未予抗癫痫治疗。随访2~18个月,1例有热性惊厥史患儿再次出现热性惊厥,其余21例患儿预后良好,患儿精神运动发育均正常。结论:RV肠炎病程初期可能伴发无热惊厥,12~18个月年龄高发,惊厥易控制,无需长期抗癫痫治疗,预后良好,未出现复发病例。更多还原

【Abstract】 Objective: To investigate the clinical features of rotavirus( RV) enteritis associated with benign infantile convulsions,and to evaluate its prognosis. Methods: A retrospective analysis of clinical manifestations,laboratory tests and treatment effect and follow-up from Jun 2008 to Oct 2012 in hospital outpatient and inpatient patients with RV enteritis associated with benign infantile convulsions was done. Results: In 22 patients,there were 14 males and 8 females,6 to 23 months of age at onset,high incidence of age 12 to 18 months accounted for 40. 90%. All cases showed generalized tonic-clonic seizures,consciousness after remission recovered rapidly with non-progressive disturbance of consciousness. Seizures of all cases occured in the course of 72 h,attack 1 occurred in 20 cases,attack 2 occurred in 2 cases,and the duration was less than 5 min. After treatment,symptom was quickly relieved.EEG showed mildly abnormal interictal performance as background electrical activity slows down in 2 cases with no epileptiform waves payment. Head CT or MRI,serum electrolytes,glucose,and cerebrospinal fluid examination were normal. Antiepileptic therapy after cessation of seizures was not given. One patient with a history of febrile seizures showed febrile seizure after follow-up 2 to 18months. Psychomotor development was normal in all cases. Conclusions: Renteritis in early course may be associated with non-thermal convulsions,high incidence of age 12 to 18 months,convulsion is easy to control without the need for long-term antiepileptic treatment,the prognosis is good and without recurrence.更多还原