【摘要】 目的研究阐明山楂(Crataegus pinnatifida Bge.)核的化学成分。方法采用硅胶柱色谱﹑Sephadex LH-20柱色谱﹑ODS柱色谱和制备HPLC等分离手段对山楂核化学成分进行分离,根据理化性质及波谱数据鉴定化学结构。结果从山楂核体积分数为70%乙醇提取物中分离得到4个化合物,分别鉴定为(2S,3R,4R)-4-[1-乙氧基-1-(4’-羟基-3’-甲氧基)苯基]甲基-2-(4-羟基-3-甲氧基)苯基-3-羟甲基四氢呋喃{(2S,3R,4R)-(4-[1-ethoxy-1-(4-hydroxy-3-methoxy)phenyl]methyl-2-(4-hydroxy-3-methoxy)phenyl-3-hydroxymethyl-tetrahydrofuran,1}、ssioriside(2)、2-(3’,4’-二甲氧基苯基)-1,3-丙二醇-1-O-β-D-吡喃葡萄糖苷[2-(3’,4’-dimethoxyphenyl)-1,3-propanediol-1-O-β-Dglucopyranoside,3)和4-O-(甘油-2-基)-二氢松柏醇1’-O-β-D-吡喃甘露糖苷[4-O-(glycer-2-yl)-dihydroconiferylalcohol-1’-O-β-D-mannopyranoside,4]。结论化合物1~4为首次从山楂属植物中分离得到。更多还原

【Abstract】 Objective To investigate chemical constituents of the seeds of Crataegus pinnatifida Bge.Methods The compounds were isolated by chromatography on silica gel,Sephadex LH-20,ODS column and HPLC,and their structures were elucidated on the basis of physico-chemical constants and spectroscopic analysis. Results Four compounds were isolated from the 70% aqueous ethanol extract of seeds of Crataegus pinnatifida and identified as( 2S,3R,4R)-4-[1-ethoxyl-1-( 4-hydroxy-3-methoxy) phenyl]methyl-2-( 4-hydroxy-3-methoxy) phenyl-3-hydroxymethyl-tetrahydrofuran( 1),ssioriside( 2),2-( 3’,4’-dimethoxyphenyl)-1,3-propanediol-1-O-β-D-glucopyranoside( 3) and 4-O-( glycer-2-yl)-dihydroconiferylalcohol-1’-O-β-Dmannopyranoside( 4),respectively. Conclusions Compounds 1-4 are isolated from the Crataegus genus for the first time.更多还原