【摘要】 目的观察2型糖尿病合并抑郁症患者镁代谢的变化及卡维地洛对其影响。方法选取2007年2月—2009年6月我院收治的2型糖尿病患者82例,将合并抑郁症53例患者作为A组,未合并抑郁症29例患者作为B组,另选取同期我院健康体检者28例作为C组。且将A组患者随机分为对照组27例和卡维地洛组26例。比较所有受试者血浆镁浓度(PMC)、单核细胞内镁浓度(MMC)、尿镁排泄量(UME);以及对照组与卡维地洛组治疗后PMC、MMC、UME变化,及其与抑郁自评量表的相关性。结果 A组PMC、MMC低于B组,UME高于B组(P<0.05)。卡维地洛组PMC、MMC高于对照组,UME低于对照组(P<0.05)。A组抑郁量表评分与UME呈正相关(r=0.41,P<0.01),与PMC、MMC呈负相关(r值分别为-0.41、-0.40,P<0.01)。结论 2型糖尿病合并抑郁症患者镁代谢紊乱与抑郁评分密切相关,卡维地洛能患者改善镁代谢及抑郁状态。更多还原

【Abstract】 Objective To investigate the effect of carvedilol on magnesium metabolism in patients with type 2 diabetes mellitus( DM) combined with depressive disorder. Methods 82 patients with DM admitted to our hospital from February 2007 to June 2009 were divided into groups A( DM combined with depressive disorder) and B( DM),and 28 healthy people were also selected as group C. A group was randomly divided into groups control and carvedilol. The levels of PMC,MMC,UME in all patients were compared,and correlation between them and self- rating depression scale analyzed. Results The levels of PMC, MMC in A group were lower than those of B group,UME higher( P < 0. 05). The levels of PMC,MMC in carvedilol group were higher than those of control group,UME lower( P < 0. 05). The self- rating depression scale in A group was positively correlated with UME( r = 0. 41,P < 0. 01),and negatively correlated with PMC,MMC( r =- 0. 41,- 0. 40,P < 0. 01). Conclusion The magnesium metabolism in patients with type 2 diabetes mellitus( DM) combined with depressive disorder is closely related to depression score,and carvedilol can improve magnesium metabolism and depressive disorder.更多还原