【摘要】 目的探讨HPV的感染方式对CIN治疗后患者HPV转阴的影响。方法采用核酸分子快速导流杂交基因芯片技术检测经病理确诊的196例CIN患者治疗前及治疗后3、6、12个月HPV的感染亚型,同期检测205例正常人的HPV感染亚型。计算治疗前以及治疗不同时间后HPV不同感染方式的感染率、基因构成,并采用SPSS18.0统计软件进行统计学分析,采用χ2检验比较组间的差异,研究不同感染方式对HPV转阴的影响。结果①CINⅠ、Ⅱ、Ⅲ级患者HPV感染率分别为65.71%(46/70)、88.23%(60/68)和91.37%(53/58),均显著高于正常人群(P<0.05)并随着CIN级别的升高而增加;②正常对照组HPV感染方式中单一高危感染所占比例最大,为6.83%(14/205),其次是混合高危感染所占比例3.90%(8/205);CIN组治疗前单一高危HPV感染率最高,为52.55%(103/196),紧接着是混合高危感染23.97%(47/196)。③多重感染HPV的CIN患者治疗后3~6个月内HPV感染率未有明显的降低,而单一感染的患者治疗后3~6个月内HPV感染率显著下降。结论 HPV多重感染不利于CIN治疗后患者的HPV的转阴。更多还原

【Abstract】 Objective To explore the relationship between the patterns of HPV infection and turning-negative of HPV. Methods The subtypes and patterns of HPV infection after the treatment of CIN for 0,3,6 and 12 month in 196 CIN patients and the 205 normal people were detected by PCR. Results ①Infection rates of CINⅠ,Ⅱ,Ⅲ were 65. 71%, 88. 23% and 91. 37%,each of which was higher than that in normal people. The Infection rates went higher with the CIN level increased. ②In the control group,single infection of high risk HPV contained the largest percentage-6. 83%,followed by the multiple in infection of high risk HPV which was 3. 90%. Similar condition was found in the CIN group,the rate of single and multiple infection of high risk HPV was 52. 55%,23. 97%. ③The infection rate of multiple HPV infection in patients after treatment for 3- 6 months did not reduce,but the infection rate of single HPV infection decreased obviously. Conclusion Multiple HPV infection prevented HPV infection changing into negative.更多还原