【摘要】 目的 通过构建新西兰大白兔腰椎脊柱结核疾病模型,比较分析MRI、CT、X线平片3种影像手段在早期脊柱结核中的诊断价值。方法 选择健康成年新西兰白兔40只,分为感染组(30只)和对照组(10只),应用外科手术建立兔脊柱结核动物模型,术后4、6、8周时行影像学、组织病理学等检查。结果 X线平片、CT、MRI显示脊柱结核病变的敏感性分别为46.13%、76.3%和92.3%;对于单个椎体结核病灶破坏范围的确定,MRI和CT较X线平片有明显优势(P<0.05);应用传统的MRI联合DWI检查方法可以早期发现椎体是否感染结核。感染组阳性兔的椎体、椎旁软组织切片HE染色示有脓细胞、类上皮样细胞或坏死灶等形成。结论 X线平片、CT、MRI 3种影像学方法能够为脊柱结核早期诊断提供一定信息,MRI扫描对脊柱结核早期诊断比其他影像学检查更为敏感。更多还原

【Abstract】 Objective To investigate the value of X-ray,CT and MRI in diagnosing early spinal tuberculosis by constructing lumbar vertebra tuberculosis model in New Zealand rabbits.Methods Forty healthy New Zealand rabbits were randomly divided into the infected group(n=30) and the control group(n=10).All rabbits were performed lumbar vertebra surgery,and then underwent imaging and histopathologic examination at 4,6,8 weeks respectively.Results The sensitivity of X-ray,CT and MRI in detecting tuberculosis lesions were 46.13%,76.3%,and 92.3%,respectively.MRI and CT were better than X-ray for displaying the destruction range limited in a single vertebra(P<0.05).Combination with routine MRI and diffusion-weighted imaging(DWI) could find the vertebra tuberculosis at the early stage.According to the HE staining,pus cells,epithelioid cells or necrosis were seen in the tissue sections of vertebra and paraspinal soft tissues in the infected group.Conclusion X-ray,CT and MRI could provide some information for the early diagnosis of spinal tuberculosis,and MRI is more sensitive.更多还原