【摘要】 目的 探讨DTI对MCI的诊断价值。方法 对26例MCI患者和年龄匹配的26例健康志愿者分别进行头颅MRI平扫及DTI检查。分别测量2组双侧额叶侧脑室前角旁、颞叶、顶叶侧脑室后角旁脑白质、海马旁回及双侧扣带回10个感兴趣区的FA值,对2组感兴趣测量结果进行独立样本t检验,分析2组间FA值有无显著性差异,并分析各感兴趣区FA值与简易精神状态量表(Mini-Mental State Examination,MMSE)及蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)的相关性。结果MCI组右侧额叶、颞叶脑白质及双侧扣带回FA值显著低于对照组(P<0.05)。右侧额叶、双侧海马旁回、左侧颞叶FA值与MoCA评分呈正相关,双侧海马旁回FA值与MMSE评分呈正相关(P<0.05)。结论 DTI可以作为MCI早期诊断的一项影像学指标,对于早期干预及提高患者的生活质量具有重要意义。更多还原

【Abstract】 Objective To evaluate the value of diffusion tensor imaging(DTI) in diagnosing MCI.Methods DTI and conventional MRI were performed in 26 patients with MCI and 26 age-matched normal control subjects(NC).FA were measured in the 10 selected white matter regions,included bilateral frontal lobe,temporal lobe,parietal lobe,parahippocampal gyrus and cingulate gyrus,in the patients with MCI(n=26) and NC(n=26).FA of each ROI(region of interest) between the patients and controls were compared by using independent sample t-test.The correlation between the FA values and the Mini-Mental State Examination(MMSE)and Montreal Cognitive Assessment(MoCA) scores was analyzed by using Spearman correlation analysis.Results Compared with NC,the FA values of the right frontal lobe,temporal lobe white matter and bilateral cingulate gyrus in the patients were significantly reduced(P<0.05).FA values of the left temporal lobe,right frontal lobe and bilateral parahippocampal gyrus were significant correlated with MoCA scores,and FA values of the bilateral parahippocampal gyrus were significant correlated with MMSE scores(P<0.05).Conclusion DTI can be used as a diagnosis index of MCI.It has important value in early intervention and improving the quality of life of patients to early diagnosing MCI.更多还原