【摘要】 目的 探讨扩散张量成像（DTI）及扩散张量纤维束成像（DTT）对中央腺体（CG）区前列腺癌（PCa）和良性前列腺增生（BPH）的鉴别诊断价值。方法 分析行常规MRI和DTI检查并经病理证实的CG-PCa 16例和BPH 30例,测量2组病变区的表观扩散系数（ADC）值和各向异性（FA）值,比较其间是否存在差异。运用种子点法对病灶最大层面对前列腺进行纤维追踪,得出DTT图,由2名资深放射科医生采用4级评分制对其进行评分,比较2组病变区纤维的走行、密度及连续性的差异。结果 BPH组ADC值为（1 357+163）×10^-6 mm²/s,FA值为（356+116）×10^-3;CG-PCa组ADC值和FA值分别为（1 058+196）×10^-6 mm²/s、（407±132）×10^-3。2组间ADC值差异有统计学意义（P<0.05）;FA值间差异无统计学意义（P>0.05）。2名医师对2组DTT图评分一致性较好（k=0.723）,CG-PCa组评分分别为2.9±0.9,2.8+1.0;BPH组为1.8±0.7;1.7±0.8。2组差异具有统计学意义（P均<0.05）。结论 ADC值在鉴别CG-PCa及BPH中具有重要价值,但FA值的意义不大。DTT图对前列腺的描述更加直观,对两者的鉴别具有一定的价值。更多还原

【Abstract】 Objective To evaluate the ability of diffusion tensor imaging（DTI） and DTT to differentiate the central prostate cancer（PCa） from benign prostate hyperplasia（BPH）.Methods 16 CG-PCa cases and 30 BPH cases proven by Histopathologically had been performed MRI and DTI.ADC values and FA values of CG-PCa and BPH were respectively measured,comparing whether there is any discrepancies between two groups.For DTT maps,two observers record the score using a four-point scale and compare the differences between two groups of lesions about fibers continuity and density.Results ADC values and FA values in BPH-PCa were:（1 357 ± 163） × 10^-6-（1 058 ± 196） × 10^-6 mm²/s,and（356±116） × 10^-3-（407 ± 132）× 10^-3 respectively.ADC value between the two groups was statistically significant difference（P<0.05）.While FA values was not（P>0.05）.Interobserver agreement regarding the scale was good（k=0.723）.The two viewers’ DTT map score of CG cancer were 2.9±0.9;2.8±1.0,the BPH were 1.8±0.7;1.7±0.8.The DTT map score between the two groups for two viewers were all statistically significant difference（P<0.05）.Conclusion ADC values can significantly differentiate CG-PCa from BPH,FA values cannot.DTT maps can describe prostate more institute,providing a certain value in distinguish PCa from BPH.更多还原