【摘要】 目的 探讨使用MR监测红霉素眼膏进入豚鼠眼眶软组织的信号演变。方法 实验动物右眼眶内注射红霉素眼膏成功后,分别在1 d、1周、2周、3周、4周进行MRI动态观察。每个时间点进行球后软组织标本HE染色。结果 右侧眶内注射红霉素眼膏后1 d、1周、2周、3周和4周后,T₂ WI上红霉素眼膏信号强度与周围肌肉软组织类似,难以辨认。T₁WI上,红霉素眼膏信号强度在1 d及1周时明显高于对侧眶脂体信号,2周及3周略高于对侧眶脂体,至4周时两者信号强度接近。HE染色显示1 d时炎性细胞浸润和组织坏死,2周时出现异物巨噬细胞及成纤维细胞;3周和4周视神经周围软组织炎症细胞逐渐消退。结论 脂肪抑制T₁WI是观察红霉素眼膏的最佳序列。T₁WI图像上的异常信号变化规律可反映红霉素眼膏进入组织后的组织病理学改变。更多还原

【Abstract】 Objective To evaluate the MRI features of erythromycin eye ointment entered into the orbital soft tissue of guinea pigs.Methods MRI was performed dynamically to observe the signal changes 1 day,1 week,2 weeks,3 weeks and 4 weeks after erythromycin eye ointment was successfully injected into orbital soft tissue of guinea pigs,as well as HE stainings to monitor retrobulbar soft tissue specimens at each time point were obtained.Results After the injection of erythromycin eye ointment 1 day,1week,2 weeks,3 weeks and 4 weeks later,the signal intensity of erythromycin eye ointment was resemble to the surrounding soft tissue and indistinguishable on T₂ WI.On T₁ WI,the signal intensity of erythromycin eye ointment was higher than that of contralateral adipose body of orbit at lday and 1 week,and slightly higher than the contralateral adipose body of orbit at 2 weeks and 3weeks,but resemblance at 4 weeks.HE staining showed that inflammatory cell infiltration and tissue necrosis at 1 day,the presence of foreign body macrophages and fibroblasts at 2 weeks,and the inflammatory cells surrounding the optic nerve gradually subsided at3 weeks and 4 weeks.Conclusion Fat-suppressed T₁ WI is the best sequence to observe erythromycin eye ointment.Abnormal signal changes on T₁ WI can reflect the histopathological changes after erythromycin eye ointment into the tissue.更多还原