【摘要】 目的 应用磁共振扩散张量成像(DTI)研究脑发育迟缓儿童常规MR平扫正常的脑白质的微结构改变。方法 分别对23例脑发育迟缓儿童(其中男12例,女11例)及23例同月龄发育正常组儿童进行常规MRI及DTI扫描。测量5个深部脑白质(内囊后肢、内囊前肢、胼胝体膝部、胼胝体压部及视放射)与4个浅部脑白质(额叶、颞叶、枕叶皮层下脑白质、半卵圆中心)感兴趣区的FA值,对2组每个部位的FA值分别进行配对t检验。结果 脑发育迟缓组深部脑白质及对照组深部、浅部脑白质及的FA值随月龄增加而升高且与月龄显著相关(P<0.05),发育迟缓组浅部脑白质FA值低于发育正常组,与月龄无明显相关(P>0.05)。脑发育迟缓组患儿浅部脑白质及深部脑白质(胼胝体膝部、视放射)FA值低于对照组(P<0.05),内囊后肢、内囊前肢及胼胝体压部FA值2组间无统计学差异(P>0.05)。结论 DTI能反映脑发育迟缓患儿轻微的脑白质细微结构的损伤,为儿童脑发育迟缓早期定量诊断提供客观依据。更多还原

【Abstract】 Objective To explore the changes of white matter microstructure by using DTI in children with developmental delay(DD) with normal routine MRI results.Methods We performed routine MRI and DTI in 23 children with DD and 23 age-matched normal children,FA values of five deep white matters(limb of internal capsule,anterior limb,genu and knee of corpus callosum and optic radiation) and four shallow white matters(frontal lobe,temporal lobe,occipital cortex,centrum ovale) were measured.FA values of the white matter for two groups were assessed by paired t tests for each region of interest.Results FA values on the deep white matter for DD,and on the deep white matter and the shallow white matter for normal development group increased with age significantly(P<0.05).FA values on the shallow white matter for DD were lower than that for normal development group,which had no significant correlation with age(P>0.05).The FA values on the shallow white matter and deep white matter(corpus callosum knee,optic radiation) for children with DD were lower than that for the control group(P<0.05),and the FA values of the limb of deep white matter(genu of corpus callosum,internal capsule and anterior limb) were no difference with the contorl group(P>0.05).Conclusion DTI may detect the changes of white matter microstructure in children with developmental delay,and provides an objective basis for quantitative diagnosis.更多还原