【摘要】 目的 通过观察肿瘤大小的动态影像变化,探讨小肝癌(直径≤30 mm)生长速率及临床相关性因素。方法 回顾性分析23例小肝癌的动态影像资料,分别测量肿瘤在初诊及复诊时的最大直径,根据数学公式计算肿瘤体积倍增时间(TVDT)。结果 23例患者肝内均为单一肿瘤,初诊及复诊肝内肿瘤的平均体积分别为4 687.8 mm~3(范围180～14 137 mm~3)、17 581.5 mm~3(范围3 054～87 113 mm~3);检查间隔平均为180 d(范围14～460 d);肿瘤平均体积倍增时间为88 d(范围19～266 d)。高、中、低分化肿瘤的平均TVDT分别为177 d、75 d和61 d。血清AFP水平越高,肿瘤体积倍增时间相对越短。结论 小肝癌的生长速率与肿瘤的组织分化程度关系密切,与血清AFP水平有弱负相关性。更多还原

【Abstract】 Objective To evaluate the growth rate of small hepatocellular carcinoma(sHCC,≤30 mm) and analyze its clinical related factors through observing the dynamical changes of tumor size.Methods The dynamic imaging findings of sHCC in 23 patients were analyzed retrospectively.The maximum diameter of the tumor and tumor volume doublings time(TVDT) were obtained at initial diagnosis and the next follow-up.Results All the patients had single tumor in the liver,and the average tumor volume were4 687.8 mm~3(range:180-14 137 mm~3) and 17 581.5 mm~3(range:3 054-87 113 mm~3) at initial diagnosis and the follow-up.Median interval between two examinations was 180 days(range:14-460 days).Median TVDT of all the tumors was 88 days(range:19-266 days),and that of well-,moderately-and poorly-differentiated tumors were 177,75 and 61 days,respectively.In addition,higher serum AFP level was related to shorter TVDT.Conclusion The growth rate of sHCC is significantly related to histological differentiation of tumor,and has a weak negative correlation with serum AFP level.更多还原