【摘要】 目的探讨血红蛋白改变对晚期胃癌患者化疗疗效及预后的预测价值。方法收集我院76例晚期胃癌患者的临床资料,应用SPSS18.0软件对化疗前后血红蛋白的改变与晚期胃癌患者化疗疗效和预后的关系进行相关分析。结果化疗前后,男性患者的血红蛋白分别为(116.72±22.01)g/L和(111.28±18.97)g/L,肝转移的患者血红蛋白分别为(116.28±18.85)g/L和(110.06±18.73)g/L,内脏转移的患者血红蛋白分别为(115.27±18.66)g/L和(109.53±18.06)g/L,差异均具有统计学意义(P<0.05)。但化疗前后血红蛋白的变化和其他参数如年龄、ECOG评分、病理分型及腹膜转移等因素无相关性。生存分析显示在化疗前出现贫血的胃癌患者的预后较差,但是差异无统计学意义(P>0.05)。结论晚期胃癌患者血红蛋白的改变与化疗疗效有密切关系,化疗后血红蛋白降低提示疗效较差,而化疗前无贫血的晚期胃癌患者显示出比较好的预后。更多还原

【Abstract】 Objective To explore the predictive value of hemoglobin change on chemotherapy and prognosis of patients with advanced gastric cancer. Methods Clinical data of 76 cases of advanced gastric cancer patients were analyzed. The correlation between hemoglobin change and the efficacy and prognosis of patients with advanced gastric cancer were analyzed by software SPSS18. 0. Results The changes of hemoglobin were analyzed before and after chemotherapy,the male patients were( 116. 72 ±22. 01) g /L and( 111. 28 ± 18. 97) g /L,patients with liver metastasis were( 116. 28 ± 18. 85) g /L and( 110. 06 ± 18. 73) g /L,and patients with visceral metastases were( 115. 27 ± 18. 66) g /L and( 109. 53 ± 18. 06) g /L,respectively,the differences had statistical significance( P < 0. 05). The changes of hemoglobin were not related with other parameters such as age,ECOG score,pathological typing and peritoneal metastasis. Survival analysis showed that gastric cancer patients with anemia before chemotherapy had poor prognosis,but the difference was not statistically significant( P > 0. 05). Conclusion There is a close relationship between the hemoglobin changes and the efficacy of chemotherapy in patients with advanced gastric cancer. Decreased hemoglobin after chemotherapy suggests poor efficacy. Patients without anemia before chemotherapy shows a relatively good prognosis.更多还原