【摘要】 目的探究手术治疗胃肠间质瘤患者的预后影响因素。方法回顾性分析56例胃肠间质瘤术后患者的临床病理资料,采用Log-rank检验和Cox比例风险模型对其影响因素进行单因素分析和多因素分析。结果 56例患者随访时间为1~38个月,中位时间为17个月,其中4例复发,2例转移,8例死亡。1、3、5年生存率分别为94.6%(53/56)、89.3%(50/56)、82.1%(46/56)。单因素分析结果显示:年龄、肿瘤直径、核分裂象和肿瘤是否破裂与患者的预后相关(P均<0.05)。多因素分析结果显示:肿瘤直径大小(RR=6.600,95%CI=2.830~15.390)、核分裂象(RR=8.457,95%CI=2.855~25.049)和肿瘤是否破裂(RR=6.586,95%CI=1.792~24.202)是胃肠间质瘤术后患者预后的独立影响因素。结论肿瘤大小、核分裂象和肿瘤是否破裂是影响胃肠间质瘤术后患者预后的重要指标。更多还原

【Abstract】 Objective To explore the prognostic factors of the surgery for gastrointestinal stromal tumor. Methods The clinical data of 56 patients with gastrointestinal stromal tumor were retrospectively analyzed. Log-Rank test were used in the univariate analysis and Cox proportional hazard model was used in multivariate analysis. Results 56 patients were followed up with a median time of 17 months( 1 to 38 months). 4 cases developed recurrence,2 cases developed metastasis and 8 cases died of gastrointestinal stromal tumor. The 1-,3- and 5-year survival rates were 94. 6%( 53 /56) 、89. 3%( 50 /56) and 82. 1%( 46 /56),respectively. Univariate analysis showed that age,tumor diameter,mitotic count and tumor rupture were related to the survival after the resection of gastrointestinal stromal tumor( all P < 0. 05). Multivariate analysis showed that tumor size( RR = 6. 600,95% CI =2. 830 ~ 15. 390),mitotic count( RR = 8. 457,95% CI = 2. 855 ~ 25. 049) and tumor rupture( RR = 6. 586,95% CI = 1. 792 ~24. 202) were independent prognostic factors of gastrointestinal stromal tumor. Conclusion Tumor size,mitotic count and tumor rupture are important prognostic index of gastrointestinal stromal tumor.更多还原