【摘要】 目的评价热疗联合同步放化疗治疗局部晚期宫颈癌的疗效和安全性。方法采用Cochrane系统Meta分析方法,检索MEDLINE、Cochrane图书馆、CNKI、VIP、万方数据库等电子资料库。由3名评价者共同评价纳入研究质量,对纳入研究进行Meta分析。结果共纳入9个随机对照研究、658例局部晚期宫颈癌。Meta分析显示热疗联合放化疗与单纯放化疗比较,可以明显改善有效率P<0.00001)、局部肿瘤完全消退率(P<0.00001)、1年无瘤生存率(P<0.00001),降低治疗后白细胞减少发生率(P=0.02),具有统计学差异;但3年生存率(P=0.19)、治疗后胃肠反应发生率(P=0.1)、膀胱反应发生率(P=0.08)、直肠反应发生率(P=0.21),两组比较无统计学差异。结论热疗联合放化疗在近期有效率和局部控制率方面较单纯放化疗有优势,不增加不良反应且可以降低治疗后白细胞减少发生率,但在长期生存率方面无明显差异。更多还原

【Abstract】 Objective To evaluate the efficacy and safety of hyperthermia combined with concurrent radiochemotherapy for locally advanced cervical carcinoma. Methods MEDLINE,The Cochrane Library,CNKI,VIP and WanFang Data were searched. The quality of included studies was evaluated and meta-analysis was performed for the results of homogeneous studies. Results 9 studies involving 658 case of locally advanced cervical carcinoma were included. Meta analysis showed that response rate( P < 0. 00001),local tumor completely regression rate( P < 0. 00001),incidence rate of leucopenia( P = 0. 02),1-year disease free survival rate( P < 0. 00001) in hyperthermia combined with concurrent radiochemotherapy were better than those of control group,but incidence rate of vomit( P = 0. 1),incidence rate of bladder reaction( P = 0. 08),incidence rate of rectal reaction( P =0. 21),3-year survival rate( P = 0. 19) of treatment group have no significant difference with control group. Conclusion Hyperthermia combined with concurrent radiochemotherapy is more effective in local tumor control and term efficacy compared with radiochemotherapy,it can reduce the incidence rate of leukopenia without increasing treatment toxicity. But there is no significant difference in terms of long-term survival rate.更多还原