【摘要】 目的观察DF、NP、TP方案化疗鼻咽癌肺转移的疗效。方法 A组初治(A1组)予DF(DDP 20 mg/m2,第1~5天;5-FU 0.5 g/m2,第1~5天)化疗,有效者(CR/PR)共3~4个周期。复治(A2组):化疗2周期未达PR改用NP(NVB 25 mg/m2,第1、8天;DDP 30 mg/m2,第2~4天)方案化疗2周期;既往曾DF化疗者予NP化疗2周期,化疗2周期未达PR改用TP(PTX 175 mg/m2,第1天,DDP 30 mg/m2,第2~4天)方案2周期。B组初治(B1组)予DF化疗,有效者(CR/PR)共3~4个周期。复治(B2组):化疗2周期未达PR改用TP方案2周期;既往曾DF化疗者TP方案化疗2周期,化疗2周期未达PR改用NP方案化疗2周期。均每21天为1个周期。结果 DF、TP初治者2组有效率相近,白细胞、血红蛋白毒性,无显著差异,P值>0.05;NP、TP方案对曾DF方案化疗者有效率42.5%、45.0%,NP、TP方案化疗无效者互换方案化疗有效率低于10.0%;TP方案初治中位进展期5.3个月。结论 NP、TP方案二线使用更有优势。更多还原

【Abstract】 Objective To observe the curative effect of DF /NP /TP regimens for nasopharyngeal carcinoma with lung metastasis. Methods Group A: In the initial treatment group A1,patients were treated with DF regimen( DDP 20 mg / m2D1-5,5-FU 0. 5 g / m2D1-5),2patients who were effective( CR or PR) were continued with the treatment for 3-4 cycles. In the retreatment group A2: patients who were not effective( SD or PD) after 2 cycles were administered with NP regimen( NVB 25 mg / m2D1、5, DDP 30 mg / m2,D2、3、4) for 2 cycles,patients were administered with NP regimen for 2 cycles of retreatment( previous chemotherapy with DF regimen),patients who were not effective( SD or PD) after 2 chemotherapy cycles were administered with TP regimen( PTX 175 mg / m2,D1,DDP 30 mg/m2,D2、3、4) for 2 cycles. Group B: In the initial treatment group B1,patients were administered with TP regimen( PTX 175 mg / m2,D1,DDP 30 mg/m2,D2、3、4). Patients who were effective( CR or PR) were continued with the treatment for 3-4 cycles. In the retreatment group B2,patients who were not effective( SD or PD) after 2 chemotherapy cycles were administered with NP regimen for 2 cycles. Patients were administered with TP regimen for 2 cycles of retreatment( previous chemotherapy with DF regimen). Patients who were not effective( SD or PD) after 2 chemotherapy cycles were administered with NP regimen for 2 cycles. Every 21days was a cycle. Results The effective rates of the 2 initial treatment groups( DF and TP) was similar( P >0. 05),the toxicities of leucocyte and hemoglobin had no significant difference( P >0. 05). The effective rates of patients who fisrt received DF regimen and retreated with NP and TP regimen were 42. 5% and 45. 0% respectively. Oppositely,patients who were administered with TP / NP regimen was replace NP / TP regimen,and their effective rates was lower than 10. 0%. 2Median time to progression was 5. 3 months with TP regimen of initial treatment. Conclusion The NP and TP regimens of second-line using are more effective.更多还原