Clinical observation of induction chrono- chemotherapy followed by concurrent chemoradiation in patients with local advanced head and neck squamous cell carcinoma
Objective: To study the efficacy and toxicities of induction chrono-chemotherapy followed by concurrent chemoradiation in local advanced head and neck squamous cell carcinoma. Methods: Fifty patients with unresected locally advanced head and neck squamous cell carcinoma were treated with induction chrono- chemotherapy of two or three cycles regimen. The TPF chemotherapy regimen was administered as follows: TXT 75mg /m2; DDP 75mg/m2,bolus infusion from 10∶ 00 to 22∶ 00,d1- 5,and 5- FU 750mg/( m2·d) bolus inf...