【摘要】 目的:分析CRP、ASO、RF和UA与紫杉醇介导的周围神经痛(peripheral nerve pain,PNP)间的关系。方法:将80例恶性肿瘤患者,分为紫杉醇和非紫杉醇组,检测化疗前后CRP、ASO、RF和UA变化,并分析与疼痛和疼痛程度关系。结果:紫杉醇和非紫杉醇组PNP发生率分别为68.42%(39/57)和17.39%(4/23),化疗前后CRP、ASO、RF和UA无统计学意义(P>0.05)。紫杉醇组化疗前后CRP、ASO、RF和UA与疼痛和疼痛程度无明显关系(P>0.05)。结论:CRP、ASO、RF和UA与紫杉醇介导的PNP无明显相关性,对PNP的发生和程度无预测意义。更多还原

【Abstract】 Objective: To evaluate the relationship between CRP,ASO,RF,UA and paclitaxel- induced peripheral nerve pain( PNP). Methods: Total of 80 cases were divided into paclitaxel and non- paclitaxel group. To detect C-reactive protein( CRP),anti- hemolytic streptococcus O( ASO),rheumatoid factor( RF) and uric acid( UA) at pro- and post- chemotherapy respectively,and analyzed the relationship between CRP,ASO,RF,UA and pain. Results: The incidence of PNP was 68. 42%( 39 /57) and 17. 39%( 4 /23) for paclitaxel and non- paclitaxel group respectively( P < 0. 05). There was no significant difference for CRP,ASO,RF and UA of pro- and post- chemotherapy,and no significance for pain and degree of paclitaxel group( P > 0. 05). Conclusion: There is no significant relationship between CRP,ASO,RF,UA and paclitaxel- induced PNP,and no significance to predict PNP development and degree.更多还原