【摘要】 目的 探讨乳腺癌患者手术及化疗后淋巴细胞亚群数值变化及临床意义。方法 选择2011年入住医院的25例病理确诊为乳腺癌且接受了手术及化疗的患者,用流式细胞仪测定其外周血CD3~+,CD4~+,CD8~+,CD4~+/CD8~+及NK细胞不同治疗时期的数值,统计学比较治疗前及治疗后不同期间T细胞亚群及NK细胞的变化,对结果进行对比分析。结果患者治疗1~3个月,CD8~+显著性降低(t=2.57);治疗3~6月,NK细胞显著性升高(t=-2.23);治疗6个月后CD3~+(t=-2.25),CD4~+(t=-2.07)显著性降低,NK细胞显著性升高(t=-3.56)。其余变化无统计学意义。结论 乳腺癌患者T细胞亚群及NK细胞能一定程度地反映患者治疗中的免疫状况,但治疗中具体数值的变化对治疗效果的评价以及预后判断的临床意义需进一步探讨。更多还原

【Abstract】 Objective To investigate the changes of lymphocyte subsets before and after the treatment with operation and chemotherapy in patients with breast cancer.Methods Using cytometer to measure lymphocyte subsets of CD3~+,CD4~+,CD8~+,CD4~+/CD8~+ and NK of 25 breast cancer patients before and after treatment.The all 25 patients were treated with operation and chemotherapy after pathological diagnosis.The article compared the figures of T cell subsets before and after treatment.Results Compared with before operation and chemotherapy,the CD8~+ statistically decreased after 1~3 months of treatment(t=2.57),and NK statistically increased after 3 ~ 6(t=- 2.23).After 6 months of treatment,the patients’ CD3~+(t=-2.25),CD4~+(t=- 2.07) were statistically lower and NK(t=-3.56) was statistically higher.There was no significant difference for other items.Conclusion Lymphocyte subsets test against breast cancer patients can reflect immunity level at a certain level during treatment.But how to explain the figures in different stage against treatment effectiveness and prognosis need further research.更多还原