【摘要】 目的 调查武汉地区泌尿道感染病原菌的分布及耐药情况,为诊断和治疗泌尿道感染提供可靠依据。方法 对2012年1月1日~2014年6月30日武汉大学人民医院泌尿道感染患者尿培养分离出的5 378株病原菌的分布及耐药性进行回顾性分析,使用BD Pheonix-100进行细菌的鉴定及药敏,真菌使用显色平板进行分离鉴定。结果 泌尿系感染患者尿液培养分离出病原菌5 378株,共104种,其中革兰阴性菌2 945株,占54.8%,以大肠埃希菌为主;革兰阳性菌1 657株,占30.8%,以肠球菌属为主;真菌776株,占14.4%。主要分离菌对抗生素的耐药情况不同:大肠埃希菌对青霉素的耐药率最高,均>83%,未发现碳青霉烯类耐药菌株;发现对万古霉素和利奈唑胺耐药的肠球菌,耐药率均在0.3%以上;MRCNS的检出率>83%。结论 泌尿系感染病原菌中以大肠埃希菌最常见。β-内酰胺酶抑制剂复合制剂可作为大肠埃希菌感染的经验性用药;MRCNS检出率增高,应引起密切关注。更多还原

【Abstract】 Objective To investigate the tendency of distribution and drug-resistance of the causative organisms of urinary tract infections(UTIs) in Wuhan,and provide reliable evidence for clinical treatment.Methods Analyzed the 5 378 stains of pathogen isolated from the urine of patients in hospital.The bacteria isolates were identified with BD Phoenix-100 while Candida isolates were identified by color plate.Results A total of 5 378 stains of pathogen had been isolated.There were 2 945stains(54.8%) of Gram-negative bacteria,1 657 stains(30.8%) of Gram-positive bacteria,776 stains(14.4%) of fungus.The rates of Escherichia coli resistant to penicillin were highest 083%),and there were no carbapenem-resistant strains.There were vancomycin and linezolid-resistant Enterococci spp strains,the lowest dection rates of which were 0.3%.The detection rate of MRCNS was over 83%.Conclusion Escherichia coli was the most common pathogens of urinary tract infection,and the β-lactamase inhibitor complex can be used as empirical treatment of E.coli infections.Thedetection rate of MRCNS increased,which shoud be kept a watchful eye on.更多还原