【摘要】 目的 探讨冠心病患者联合检测血清ⅡA分泌型磷脂酶A₂（secretory groupⅡA phospholipase A₂,ⅡA-sPLA₂）及脂蛋白相关磷脂酶A₂（LP-PLA₂）对于其诊疗的意义。方法 对健康对照组50例、急性心肌梗死（AMI）组13例、稳定型心绞痛（UAP）组17例和不稳定型心绞痛（SAP）组70例的生化指标（主要ⅡA-sPLA₂和LP-PLA₂水平）进行测定,统计分析各组之间的差异是否有统计学意义。结果 随着冠心病患者病变程度加剧,HDL水平有降低的趋势,即AMI组比SAP和UAP组患者的HDL水平均高,三组相比差异均有统计学意义（t=3.013³.987,均P>0.05）。ⅡA-sPLA₂和LP-PLA₂在冠心病各亚型患者中的水平明显比对照组高,且AMI组比SAP和UAP组,SAP比UAP患者的水平均高,差异有统计学意义（t=3.507⁹.967,均P<0.05）。ⅡA-sPLA₂和LP-PLA₂指标之间呈正相关关系（r=0.657,P<0.05）,HDL分别和ⅡA-sPLA₂与LP-PLA₂之间呈显著的负相关关系（r=—0.351,—0.294,均P<0.05）。结论 ⅡA-sPLA₂与LP-PLA₂含量将可能是治疗冠状动脉粥样硬化和预防心血管疾病的新指标。更多还原

【Abstract】 Objective To explore the significance of study of the Ⅱ A-sPLA₂ and LP-PLA₂ for coronary artery disease.Methods The normal group,AMI group,UAP group,SAP group values of Ⅱ A-sPLA₂ and LP-PLA₂ were mainly measured,and toobserve the difference of the two indicators in each group,and then the results were statistically analyzed.Results There was a tendency of improved to HDL indicator.There were significant differences among AMI group,UAP group and SAP group（r=3.013³.987,P<0.05）.The Ⅱ A-sPLA₂ and LP-PLA₂ levels in CAD groups were higher than the normal,also there were significant differences among CAD groups（t=3.507⁹.967,P>0.05）,and the two indicators levels were highest in AMI group.Meanwhile,there were positively correlated with Ⅱ A-sPLA₂ and LP-PLA₂ levels in CAD groups（r =0.657,P<0.05）.HDL with the Ⅱ A-sPLA₂ or LP-PLA₂ levels respectively were negatively correlated（r= — 0.351,—0.294,P>0.05）.Conclusion Ⅱ A-sPLA₂ and LP-PLA₂ had close relationships with coronary artery disease,so study of the two indicators would be helpful to monitor and control the occurrence and the development of coronary artery disease.更多还原