【摘要】 为探讨羌活(Rhizoma Notopterygii)水提物和75%醇提物对小鼠腹泻的止泻作用,分别用羌活水提物高、低剂量(5、15g/kg)和75%乙醇提物高、低剂量(5、15g/kg)对番泻叶(Folium Sennae)、蓖麻油和硫酸镁引起的小鼠腹泻进行灌胃治疗,记录灌胃前后小鼠腹泻次数及小鼠小肠墨汁推进率,比较不同羌活提取液的止泻效果.结果显示:在番泻叶、蓖麻油和硫酸镁各腹泻模型组,羌活醇提物低剂量组分别在1h及4h、1~8h、3h有显著性差异,高剂量组分别在1h、1~8h、2~3h有极显著差异;水提物高剂量组分别在1~3h、1~8h、3h有显著性差异,低剂量组仅在番泻叶、蓖麻油腹泻模型1~2h、1~8h有显著差异,在硫酸镁腹泻模型组无显著差异.说明羌活醇提物和水提物主要对渗出性腹泻止泻效果显著,水提物止泻效果显著强于醇提物,对小肠蠕动紊乱所致的腹泻作用不显著.更多还原

【Abstract】 To investigate the effects of Notopterygium water extract and 75% ethanol extract on mice diarrhoea,Notopterygiumaqueous extract with high and low dose(5,15g/kg),and 75% ethanol extract with high and low dose(5,15g/kg),were used respectively to treat diarrhoeal mice induced by Folium Sennae,castor oil and magnesium sulphate through gavage.The frequency of diarrhea and ink advance rate of small intestine before and after gavage were recorded to compare the anti-diarrheal effects of different Notopterygiumextract.The following results obtained.Comparing with the modle groups of senna,castor oil and magnesium sulfate,the lowdose group of Notopterygiumalcohol extract has significant difference in 1h,4h,1~8hand 3h,and the high-dose group has very significant difference in 1h,1~8h,2~3h.The high-dose group of Notopterygiumaqueous extract has significant difference in 1~3h,1~8h,3h,and only senna and castor oil diarrhea model group has significant difference in 1~2h,1~8hwith the low-dose group,and there are no significant differences in the magnesium sulfate diarrhea model group.Therefore,the effect of Notopterygium ethanol extract and water extract are significant mainly in exudative diarrhea anti-diarrheal,and the effect of aqueous extract of anti-diarrhea is significantly stronger than that of the alcohol extract.Additioually,Notopterygiumhas no significant effect in anti-diarrheal caused by small bowel disorders.更多还原