【摘要】 利用近红外光谱技术实时监测与评估大鼠颅脑损伤脱水治疗效果。采用Feeney’s自由落体法建立大鼠颅脑损伤模型,然后使用不同剂量甘露醇进行脱水治疗,并采集伤后及治疗过程中优化散射系数(μ′s)和颅内压(ICP)的值。结果显示,伤后1h大鼠脑组织发生水肿,伤后72h左右达到峰值,之后开始逐渐减小。注射甘露醇的治疗组μ′s与ICP值在给药后均下降,大剂量甘露醇(2g/kg)平均下降幅度大,平台期持续时间长,总体下降情况更为明显。由此我们得到结论:μ′s和ICP的变化趋势一致,可以代替ICP作为监测脑水肿的参数。更多还原

【Abstract】 We used near-infrared spectroscopy technology to monitor and assess the treatment effect of dehydrating agent in injured rat brain in real time style.We employed the brain edema model in rats resulting from Feeney’s freefall damage,then treated with different doses of mannitol,and collected reduced scattering coefficient(μ′s)and intracranial pressure(ICP)values after the injury and during the treatment.The results showed that brain edema happened 1hafter the injury in rats’ brain tissue,peaked around 72 hafter injury,and then began to decrease gradually.The reduced scattering coefficient and ICP values of the treatment group injected with mannitol all decreased after administration.Compared with the effect of low-dose mannitol treatment,that of high-dose mannitol treatment was much better.The duration of the plateau was longer and most experiments results declined significantly.From this we conclude that the reduced scattering coefficient and ICP are consistent with the trend changes,and the reduced scattering coefficient could be used as an indicator for monitoring cerebral edema.更多还原