【摘要】 围术期最常用,最重要的药物是全身麻醉药(包括吸入麻醉药和静脉麻醉药),麻醉药是适应手术的需要而出现的,经过长时间的发展,它的药理作用也越来越完善。在过去几年里很多研究报道的麻醉药的药理作用与介导的细胞凋亡之间的关系主要集中在神经系统。然而,麻醉实践中大部分麻醉药物都在肝脏代谢,已有证据表明麻醉药对肝细胞也有影响。麻醉药介导的细胞凋亡作用可能与caspase通路,Bcl-2家族,TRADD,FADD等多种因素有关。但不是所有麻醉药都对肝细胞有凋亡作用,部分还具有保护作用。因此本文就现有的麻醉药对肝细胞凋亡中的作用进行了综述。更多还原

【Abstract】 General anesthetics(including inhaled anesthetics and intravenous anesthetics) are the most common and important drugs during perioperative period. The advent of anesthetics is adapt to surgery. After a long period of development, its pharmacological effects have been more perfect. In the past few years, many studies have reported a relationship focused on the nervous system between anesthetic pharmacological effects and the apoptosis mechanisms. However, majority of anesthetic drugs are metabolized in the liver during the anesthesia practice. There are evidences that anesthetics also have effects on the liver cells. Anesthetics mediated apoptosis may be associated with caspase pathway, Bcl-2 family, TRADD, FADD. But not all the anesthetics cause liver cells apoptosis, even some may have protective effects. Therefore, this paper have reviewed the role of anesthetics on the hepatic apoptosis.更多还原