【摘要】 Eph/Ephrin家族是受体酪氨酸激酶家族中的最大亚族,在生理和病理性血管形成中起重要作用。眼部血管生成是糖尿病视网膜病、早产儿视网膜等眼部疾病致盲的重要因素,Eph和Ephrin基因在上述眼部疾病中有不同程度表达改变。Eph受体及其配体Ephrin之间的双向信号机制是Eph-Ephrin发挥功能的主要方式。本文就Eph-Ephrin双向信号机制在眼部血管新生中的作用进行综述。更多还原

【Abstract】 Eph/Ephrin, the largest subfamily of receptor tyrosine kinases(RTKs), plays an important role in both physiological and pathological angiogenesis. Ocular angiogenesis is an important pathological phenomenon of some ocular disorders such as diabetic retinopathy and retinopathy of prematurity, which may result in blindness. It has been reported that there are alteration of Eph and Ephrin expression in ocular angiogenesis-related disorders, suggesting that Eph-Ephrin maybe play roles in ocular angiogenesis. Eph-Ephrin exerts their roles by the bidirectional signaling between Eph receptor and Ephrin ligand. This review focused on the roles of bidirectional signaling of Eph-Ephrin in ocular angiogenesis.更多还原