【摘要】 目的:探讨血清降钙素原在感染性休克患者中的表达及与APACHEⅡ评分的相关性分析。方法:选取2012年1月至2013年9月我院收治的58例感染性休克患者,设为感染性休克组,早期采取液体复苏的方法进行救治。另选取同期于我院体检的年龄、性别与之相匹配的52例健康人设为对照组。测定两组不同时间的血清PCT含量,对APACHEⅡ评分进行评定,并进行统计学分析。结果:感染行休克组患者的复苏液体量最少为4332mL,最多为10645mL,平均为(7602.85±1628.47)mL,复苏达标的平均时间为(17.67±3.75)h。感染性休克组患者血清PCT含量治疗后24h为(8.77±4.66)μg/L,明显低于治疗前的(17.78±5.89)μg/L;感染性休克组患者治疗前与治疗后24h血清PCT含量相比于对照组受试者的(0.03±0.01)μg/L均显著提高;感染性休克组患者治疗前与治疗后24hAPACHEⅡ评分分别为(16.68±3.27)分、(10.46±3.18)分,相比于对照组的(7.22±1.15)分均显著提高;感染性休克组患者APACHEⅡ评分治疗后24h明显低于治疗前。差异有统计学意义(P<0.05)。感染性休克组治疗前后PCT含量与APACHEⅡ评分均呈一定的正相关(P<0.05);PCT含量变化与快速复苏的液体量呈一定的负相关(P<0.05);而与APACHEⅡ评分不存在明显的相关性(P>0.05)。结论:将血清降钙素原应用于感染性休克患者的诊断及治疗过程中评估病情变化,能够为液体复苏提供有效的指导。血清降钙素原含量与APACHEⅡ评分呈正相关,但其变化与APACHEⅡ评分不存在相关性,而与复苏液体量呈负相关。更多还原

【Abstract】 Objective: To investigate correlation analysis of serum procalcitonin level and APACHE Ⅱ score in patients with septic shock. Methods: 58 cases of patients with septic shock from January 2012 to September 2013 in our hospital were selected and set as septic shock group,early fluid resuscitation approach were given for treatment. 52 healthy subjects admitted in hospital for physical examination matched in age and sex were selected as controls. Serum PCT levels and APACHE Ⅱ scores of the two groups at different times were assessed and analyzed statistically. Results: The amount of fluid resuscitation of septic shock patients was 4332ml at least, 10645ml at most, and average(7602.85 ±1628.47) ml, the average recovery time for compliance was(17.67 ±3.75) h. 24h after treatment, Serum PCT levels in septic shock group was(8.77±4.66) μg / L, significantly lower than before treatment(17.78±5.89) μg / L. Before treatment and 24h after treatment, serum PCT levels of septic shock groups were both significantly higher than the control group(0.03±0.01) μg / L; In septic shock group, before and after treatment 24h APACHE Ⅱ scores were(16.68±3.27) points and(10.46 ±3.18) points respectively, significantly higher than that of the control group(7.22 ±1.15 points). The septic shock patients’ APACHE Ⅱ score was significantly lower than before the treatment and the difference was statistically significant(P<0.05). Septic shock group before and after treatment PCT levels and APACHE Ⅱ score showed a positive correlation(P<0.05). PCT levels change and the amount of liquid fast recovery and correlated(P<0.05), while the APACHE Ⅱ score presents no obvious correlation(P> 0.05). Conclusion: Appication of serum procalcitonin in the diagnosis and treatment of patients with septic shock can assess changes in condition and provide effective guidance for fluid resuscitation. Serum procalcitonin levels and APACHE Ⅱ scores were positively correlated, but the changes part were not correlated and APACHE Ⅱ score was negatively correlated with the amount of fluid resuscitation.更多还原