【摘要】 目的:探讨内蒙古地区临床危重患者常见感染细菌耐药基因的检测及耐药性相关因素,以便临床合理运用抗菌药物,为病原菌感染的预防和控制提供依据。方法:选取2010年1月至2013年1月在我院重症监护室治疗的病例中检测出的215株细菌为研究对象,运用相关的检测手段分析细菌的耐药性和耐药基因情况。结果:经过临床的检测后得出大肠埃希菌、肺炎克雷伯菌、鲍氏不动杆菌分别为85株、55株和75株,其中产ESBLs大肠埃希菌54株,非产ESBLs大肠埃希菌31株;产ESBLs肺炎克雷伯菌15株,非产ESBLs肺炎克雷伯菌40株。大肠埃希菌、肺炎克雷伯菌、鲍氏不动杆菌对美罗培南、亚胺培南的敏感性最高,且在产与非产ESBLs菌株耐药上比较有差异性(P<0.05);产与非产ESBLs菌株耐药基因检测方面比较无明显差异性(P>0.05)。结论:大肠埃希菌、肺炎克雷伯菌、鲍氏不动杆菌均存在多重耐药情况,且耐药与喹诺酮耐药机制有一定的相关性。更多还原

【Abstract】 Objective:To study the clinical common in Inner Mongolia in critical patients infected with the bacteria resistant gene detection and resistance related factors,in order to clinical rational use of antimicrobial agents for pathogen infection provides the basis for the prevention and control.Methods:we chose from March 2011 to March 2012 in our hospital medicine in treatment of 159 patients and the data were retrospectively analyzed,the common infection of bacteria to carry on the analysis,using the related detection means to the analysis of bacterial resistance situation.Results:The number of Escherichia coli,klebsiella pneumoniae "bacteria,bowman’s acinetobacter were 85,55,75,The number of ESBLs Escherichia coli was 54,Non-ESBLs Escherichia coli was 31,The number of ESBLs klebsiella pneumoniae" bacteria,was 15,Non-ESBLs klebsiella pneumoniae "bacteria,was 40.Escherichia coli,klebsiella pneumoniae" bacteria,bowman’s acinetobacter to meropenem,imine culture south the highest sensitivity,and in the production and the producing ESBLs strains resistant some differences,P< 0.05,there is statistical significance;Production and the producing ESBLs strains resistant gene detection were no significant difference,P>0.05,no statistical significance.Conclusion:Escherichia coli,klebsiella pneumoniae bacteria,bowman’s acinetobacter there were multiple drug resistance,and resistance to quinolones mechanisms of resistance to have certain relevance.更多还原