【摘要】 目的:分析紫癜性肾炎患者的临床及病理资料,探讨两者之间相关性,并利用临床指标评估肾脏损伤的程度。方法:收集哈尔滨医科大学附属第一医院肾内科肾活检及临床确诊为紫癜性肾炎的101例住院病人。分别比较年龄、病程、紫癜出现的次数、血压、蛋白尿、尿红细胞数、血肌酐、血浆白蛋白及纤维蛋白原与肾脏损伤程度之间的关系。结果:紫癜性肾炎肾脏损伤程度与病程(P<0.0001)、血压(P<0.0001)、蛋白尿(P<0.0001)、血肌酐(P<0.0001)、纤维蛋白原(P=0.0189)呈正相关;与血浆白蛋白(P<0.0001)呈负相关;与年龄(P=0.6515)、紫癜出现的次数(P=0.912)、血尿(P=0.0781)没有统计学差异。结论:紫癜性肾炎的临床表现及化验指标,如紫癜的病程、紫癜出现的次数、血压、蛋白尿、血肌酐、血浆白蛋白及纤维蛋白原等与肾脏损伤的严重程度密切相关,通过对临床表现及化验指标的评价分析可以对肾脏损伤程度作出初步评估,对肾活检患者的选择、治疗方案的确定及判断预后均有一定的指导意义。更多还原

【Abstract】 Objective: To study the relationship between clinical manifestation and pathological feature with Henoch-Schonlein purpura nephritis, and to assess the degree of renal injury severity by clinical indicators. Methods: We collected the data of 101 HSPN patients hospitalized from the Department of Nephrology the First Affiliated Hospital of Harbin Medical University, which confirmed by pathological feature and renal biopsy. Then we compared the relationship between clinical indicators and the degree of renal injured. The clinical indicators included: age, the course of Henoch-Schonlein purpura nephritis, the times of purpura, blood pressure, proteinuria, hematuria, serum creatinine, serum albumin, fibrinogen. Result: There was a positive correlation between the course of Henoch-Schonlein purpura(P<0.0001), blood pressure(P<0.0001), proteinuria(P<0.0001), serum creatinine(P<0.0001), fibrinogen(P=0.0189) and the degree of renal injury severity. At the meanwhile, serum albumin levels decreased with renal pathological scores increased(P<0.0001). But it were not statistically significant with age(P=0.6515), the times of purpura(P=0.912), and hematuria(P=0. 0781). Conclusion: This study shows that the correlation between clinical indicators(such as the course of Henoch-Schonlein purpura nephritis, the times of purpura, blood pressure, proteinuria, serum creatinine, serum albumin and fibrinogen) and the severity of clinical renal injured of HSPN. By the evaluation of clinical indicators, we can evaluate the degree of renal injured severity preliminary. And there was a guiding significance of how to choose patients who needed renal biopsy of HSPN, the determination of the treatment program and the judgment of prognosis.更多还原