【摘要】 目的:探讨卒中相关感染的危险因素及其与免疫抑制的相关性。方法:选取2010年4月至2013年7月我院收治的164名急性卒中患者的临床资料,依据入院7 d内是否存在感染将其分为感染组和非感染组。对两组的临床资料、及淋巴细胞及T淋巴细胞亚群的监测结果分别进行单因素分析及多因素Logistic回归分析。结果:164例急性卒中患者在发病后7天内64例出现SAI,SAI的发生率为39.02%,平均感染时间为2.58±0.94天。单因素分析发现,两组患者的意识障碍、吞咽困难、留置胃管、留置导尿、NIHSS评分等因素相比,差异均具有统计学意义(P<0.05)。感染组的淋巴细胞计数、淋巴细胞百分比及CD3+、CD4+、CD8+T淋巴细胞水平均明显低于非感染组(P<0.05)。多因素Logistic回归分析可知,吞咽困难、第3天NIHSS评分、CD4+T淋巴细胞成为影响SAI发生的独立危险因素(P<0.05)。结论:吞咽困难、第3天NIHSS评分、CD4+T淋巴细胞是影响脑卒中相关感染发生的独立危险因素,SAI的发生与免疫抑制存在显著的相关性。更多还原

【Abstract】 Objective: To explore the risk factors of stroke-related infection and its correlation with immune suppression. Methods: April 2010 to July 2013 in our hospital 164 patients with acute stroke clinical data, based on the existence of hospital infection within 7 d infection will be divided into groups and non-infected group. The clinical data of the two groups, and lymphocyte and T lymphocyte subsets monitoring results were analyzed by univariate analysis and multivariate Logistic regression analysis. Results: 164 patients with acute stroke patients within 7 days after the onset of 64 cases occurred SAI, SAI incidence rate of 39.02%, the average infection time was 2.58 ±0.94 days. Univariate analysis found that two groups of patients of consciousness, difficulty swallowing, indwelling stomach tube, indwelling catheterization, NIHSS score and other factors, the differences were statistically significant(P<0.05). Infection of lymphocyte count, percentage of lymphocytes and CD3+, CD4+, CD8+T lymphocytes were significantly lower than non-infected group(P<0.05). Multivariate Logistic regression analysis, difficulty swallowing, the first three days NIHSS score, CD4+T lymphocytes an impact on stroke-related infection were independent risk factors(P<0.05). Conclusion: Difficulty swallowing, the first three days NIHSS score, CD4+T lymphocytes are the effects of stroke-related infection is an independent risk factor, SAI immunosuppressive occurrence and there is a significant correlation.更多还原