【摘要】 近20多年来人们对脑缺血损伤的保护研究很多,但真正能将脑缺血保护从基础研究应用到临床治疗的措施甚少。多数基础研究表明缺血预处理对大鼠脑缺血具有保护作用,然而由于脑缺血的不可预见性,研究者们将目标转向了缺血后处理。远端缺血后处理是指在非缺血器官交替实施短时间的缺血和再灌注后对缺血器官所产生的作用。由于脑组织本身对缺血的敏感,很难控制缺血后处理的程度,因此远端缺血后处理被应用到脑缺血的保护研究具有很强的临床应用价值,其机制可能与氧自由基、神经传导、蛋白质、内质网应激、Akt信号通路、线粒体途径、mitoKATP和阿片受体有关。本文主要就近几年远程缺血后处理对脑缺血保护的概念、实施方法、保护作用及分子机制做一综述。更多还原

【Abstract】 Nearly 20 years,people have studied much on the protection of cerebral ischemic injury,but it`s very little to take cerebral ischemia protection from basic research to clinical application about treatment measures.Many basic researches suggest that ischemic preconditioning on cerebral ischemia in rats have protective effect,however due to the unpredictability,researchers have turned to the ischemic postconditioning.Remote ischemic postconditioning is refered to the effect of the non ischemic organs carry out alternately short periods of ischemia and reperfusion on ischemic organ.Because the brain itself is sensitive to ischemia,it is difficult to control the degree of ischemia after treatment,so the the application of remote ischemia postconditioning on cerebral ischemia protection research has the very important clinical application value,oxygen radicals,nerve conduction,protein,endoplasmic reticulum stress,Akt,mitochondrial pathway and mitoKATP are involved.This article is aimeed to review the protection concept,implementation method,protective effect and molecular mechanisms on cerebral ischemia with remote ischemia postconditioning.更多还原