【摘要】 目的:探讨PBRM1和P21蛋白在子宫内膜癌中的表达和临床意义。方法:应用免疫组化方法对105例子宫内膜癌组织进行PBRM1和P21蛋白检测。结果:子宫内膜癌中PBRM1和P21的阳性表达率分别为62.86%和80%;癌旁组织PBRM1和P21阳性表达率分别为45.71%和34.2%,子宫内膜癌组织表达高于癌旁组织(P<0.05);PBRM1和P53阳性表达与组织学类型、浸润深度、淋巴结转移、组织学分级、临床TNM分期相关(P<0.05),与患者年龄无关(P>0.05)。PBRM1和P21的表达呈正相关(P<0.05)。结论:PBRM1和P21表达水平与子宫内膜癌组织的病理分级和临床分期的增高而增高,对其进行监测对子宫内膜癌的诊断、治疗及预后有指导意义。更多还原

【Abstract】 Objective:To study the expression of PBRM1 and P21 in endometrial cancer and its clinical significance.Methods:The protein of PBRM1 and P21was examined in 105 cases of endometrial cance immunohistochemistry.Results:The positive expression rate of PBRM1and P21 in the carcinoma and the normal tissues of endometrial cancer was 62.86% and 80%,respectively,which had significant difference(P <0.05).While the positive expression rate of P53 was 45.71% and 34.2%,respectively,which significant difference(P<0.05).The expressive of both PBRM1 and P53 were related to different tissue types,the depth of invasion,lymph node metastasis,histology stage,the clinical stage(P<0.05),no correlation existed with age of endometrial cancer.(P>0.05).Conclusion:The expression level of PBRM1 and P21 increased markedly with the clinical stage or clinical grade of endometrial cancer.The mutation of gene and hormonal imbalalance may play an important role in endomefriun Oncogenesis and metaetasis of carcinoma of endometrium.更多还原