【摘要】 目的探讨重组人粒细胞巨噬细胞集落刺激因子(rhGM-CSF)凝胶在Ⅱ~Ⅲ度压疮创面治疗和护理中的临床应用效果。方法将85例(98处)Ⅱ~Ⅲ度压疮患者分为两组,试验组创面应用重组人粒细胞巨噬细胞集落刺激因子凝胶治疗,对照组创面应用磺胺嘧啶银(SD-Ag)霜治疗,观察、对比两组患者治疗效果、创面细菌培养及PUSH评分结果。结果试验组平均愈合时间为16.75 d±1.22 d,有效率为96.49%,对照组平均愈合时间为21.73 d±4.55 d,有效率为78.05%。换药14 d后,试验组患者创面PUSH评分为5.76±2.59,对照组为8.59±3.23,各项指标对比,差异均具有统计学意义(P<0.01)。结论重组人粒细胞巨噬细胞集落刺激因子凝胶能抑制Ⅱ~Ⅲ度压疮创面细菌繁殖,促进肉芽组织生成,显著缩短创面愈合时间。更多还原

【Abstract】 Objective To investigate the clinical efficacy of Recombinant Human Granulocyte-macrophage Colony StimulatingFactor(rhGM-CSF) Gel in the wound treatment and care of Ⅱ-Ⅲ degree pressure ulcer.Methods 85 patients(98 wounds) with Ⅱ-Ⅲ degree pressure ulcer were divided into a treatment group and a control group.The treatment group was treated with rhGM-CFS Gel and the control group was treated with SD-Ag Cream.The therapeutic effect,wound bacterial culture result and PUSH scoring were observed and comparedbetween the two groups.Results In the treatment group,the average healing time was 16.75 d ± 1.22 d and the effective rate was 96.49%.while they were 21.73 d ±4.55 d and 78.05%respectively in the control group.After 14 d dressing change,the PUSH scoring was 5.76 ±2.59(in the treatment group) and 8.59 ±3.23(in the control group) respectively.Comparisonof the indicators between the two groupsshowed statistically significantdifferences(P<0.01).Conclusion RhGM-CSF Gel can inhibit bacteria reproduction,promote granulation tissue formation and shorten wound healing time significantly in the treatment of Ⅱ-Ⅲ degree pressure ulcer.更多还原