Random- Centroid Optimization( RCO) methodology was used to optimize the extraction technology of flavonoids and polyphenols from the Coreopsis tinctoria Nutt.grow in xinjiang.The results showed that Subcritical Water Extraction was a effective methods for flavonoids and polyphenols.By comparing the extraction temperature,solid- liquid ratio and extraction time,the optimum extraction process of flavonoids and polyphenols from the Coreopsis tinctoria Nutt.has been established as follows: extraction temperatu...