【摘要】 miR-26家族是由miR-26a、miR-26b、miR-1297及miR-4465等序列相似、结构相仿、种子区序列相同(UCAAGUA)的微小RNA(microRNAs,miRNAs)组成。多种组织细胞分化过程中伴有mi R-26家族表达的增加,其异常表达与特发性肺纤维化、原发性胆汁性肝硬化、多发性硬化及阿尔茨海默病等有关。近年研究报道,多种肿瘤组织亦存在mi R-26基因表达紊乱,并与肿瘤的发生发展密切相关。就miR-26家族及其调控的靶基因与肿瘤关系的研究进展进行综述。更多还原

【Abstract】 miR-26 family is composed of 4 miRNAs, including miR-26 a, miR-26 b, miR-1297 and miR-4465, which share same seed region(UCAAGUA) and similar sequence and structure. It is known the expression of miR-26 members was increased during osteogenic differentiation, smooth muscle cell(SMC) differentiation and neurogenesis, and etc. The disturbance of miR-26 family gene expression was related with biliary cirrhosis, pulmonary fibrosis, multiple sclerosis and Alzheimer’s disease, etc. It was reported recently the disturbance of miR-26 expression existed in tumors and it might play an important role in tumorigenesis and tumor development. In this review, the progress on the relationship between miR-26 family and their target genes and malignant tumors are summarized.更多还原