【摘要】 目的探讨儿童期反复发作的睑缘炎导致相关性干眼治疗后泪膜功能的变化。方法选取2013年4月~2014年1月就诊于山西省眼科医院门诊角膜科的患儿36例(55只眼)进行观察,治疗前后分别行眼前节检查,对比睑板腺功能评分、泪膜破裂时间(trar break-up time,BUT)检查、泪液分泌试验(Schirmer I test,SIt)及角膜荧光素染色试验(fluorescein,FL)。结果患儿的泪膜功能均有不同程度的异常。患者治疗前后的睑板腺功能评分、BUT试验和FL评分有明显变化;SIt差异无统计学意义(P>0.05);睑板腺功能评分与BUT呈负相关(r=-0.667,P=0.000),与FL呈正相关(r=0.722,P=0.000),与SIt无明显相关性(r=-0.108,P=0.457)。结论在临床上睑缘炎导致的蒸发过强型干眼患儿,若睑缘炎得到良好的治疗,并且联合使用人工泪液,配合局部外用中药,患儿的自觉症状能够明显好转,泪膜稳定性有所提高,且可防止睑缘炎的复发。更多还原

【Abstract】 Objective To discuss the changes in tear film function after treatment in relevant dry eye induced by childhood recurrent blepharitis. Methods Thirty- six cases( 55 eyes) in Clinical Cornea Department of Shanxi Eye Hospital were selected for observation from April 2013 to January 2014. Before and after treatment,the slit- lamp examination,meibomian gland function,tear film break- up time( BUT) examination,Schirmer I test( SIt) and corneal fluorescein staining test( FL) were performed. Results The tear film function was abnormal to different extents in children. The meibomian gland function score,BUT test and FL score changed apparently in comparison before and after treatment. The difference in SIt was not significant( P > 0. 05). The meibomian gland function score was negatively correlated with SIt( r =- 0. 108,P = 0. 457). Conclusion In clinic,blepharitis leads to evaporative- type dry eye disease in children. If blepharitis is treated well in combination with the application of artificial tears and topical herbal medicine,the subjective symptoms can be relieved apparently and tear film stability be improved. Moreover the recurrence of blepharitis can be prevented.更多还原