【摘要】 目的:观察鳖甲煎丸对糖尿病合并动脉粥样硬化大鼠血脂、内皮素(ET)、一氧化氮(NO)、基质金属蛋白酶9(MMP-9)的影响。方法:将造模成功后雄性SD大鼠随机分为空白组、模型组、鳖甲煎丸低剂量组、鳖甲煎丸高剂量组、血脂康组。灌胃8周后,观察不同组别大鼠血脂、血清ET-1、血清NO、MMP-9的变化。结果:与空白组比较,模型组血清NO水平显著降低(P<0.05),ET-1水平明显升高(P<0.05);与模型组比较,鳖甲煎丸高、低剂量组、血脂康均能显著降低血清ET-1含量(P<0.05或P<0.01)、升高NO含量(P<0.05或P<0.01)、MMP-9表达明显下降(P<0.05)。结论:鳖甲煎丸可能通过调脂、保护血管内皮细胞、稳定斑块等作用起到抗动脉粥样硬化的作用。更多还原

【Abstract】 This article was aimed to observe the preventive effect of diabetes with atherosclerosis(AS) treated with Bie-Jia-Jian Pill(BJJP) on level of blood lipids, endothelin(ET), nitric oxide(NO), and matrix metalloproteinase-9(MMP-9). Male SD rats were randomly divided into 5 groups, which were the blank group, model group, low-dose BJJP group, high-dose BJJP group and Xue-zhi-kang(XZK) group, to observe changes on the level of blood lipids,ET-1, NO and MMP-9 within 5 groups after 8-week administration. The results showed that compared with the blank group, the level of the content of NO in the model group was significantly decreased(P < 0.05), the level of ET-1 was significantly increased(P < 0.05). Compared with the model group, the high-dose and low-dose BJJP group as well as XZK group can significantly decrease the level of ET-1(P < 0.05, or P < 0.01), increase content of NO(P < 0.05, or P < 0.01), and decrease the expression of MMP-9(P < 0.05). It was concluded that the BJJP can regulate blood lipids, protect endothelial cell of blood vessels, stabilize plaques for the anti-AS effect.更多还原