【摘要】 目的对海南地区健康成人25羟基-维生素D(25OH-D)参考区间进行调查,为合理补充维生素D提供科学依据。方法选择海南地区生活背景相似、年龄不同的健康体检者1 978名(男1 008名、女970名),收集对象的基本资料,采用电化学发光法测定所有对象的血清25OH-D水平。按性别和年龄分别分组进行统计分析。结果调查所用的25OH-D检测系统准确度、精密度良好。血清25OH-D水平呈非正态分布,采用百分位数(P2.5~P97.5)设立参考区间。男、女性间血清25OH-D水平差异有统计学意义(P<0.01);≤50岁及>50岁男、女性之间血清25OH-D水平差异均有统计学意义(P均<0.01);男性≤50岁的参考区间为6.77~26.80 ng/mL,>50岁的参考区间为4.51~19.73 ng/mL;女性≤50岁的参考区间为5.96~24.79 ng/mL,>50岁的参考区间为3.71~16.34 ng/mL。结论针对海南地区人群的实际情况,建立了不同性别和年龄的25OH-D参考区间。更多还原

【Abstract】 Objective To survey the reference intervals of serum 25-hydroxy vitamin D(25OH-D) from adults in Hainan area,and provide scientific reference for reasonable supplement of vitamin D. Methods Basic data of 1 978 healthy subjects(1 008 males and 970 females) with similar livelihood background and different ages were collected, and the level of serum 25OH-D was analyzed by electro-chemiluminescence. The subjects were classified according to sex and age,and the results were analyzed statistically. Results The accuracy and precision of the 25OH-D detection system were good,and the levels of serum 25OH-D had non-Gaussian distribution. The reference intervals were established by percentile(P2. 5-P97. 5). There were statistical significances of 25 OH-D between males and females(P < 0. 01). There was statistical significance between ≤50 years old and > 50 years old among males and females(P < 0. 01). The reference interval of males ≤50 years old was 6. 77-26. 80 ng/mL,and that of males > 50 years old was 4. 51-19. 73 ng/mL. The reference interval of females ≤50 years old was 5. 96-24. 79 ng/mL and that of females > 50 years old was 3. 71-16. 34 ng/mL. Conclusions The reference interval for specific sex and age should be established for the population of Hainan area.更多还原