【摘要】 目的探究美沙拉嗪对溃疡性结肠炎患者的临床疗效及对ESR、PLT、D-二聚体的影响。方法选取贵阳医学院第三附属医院、贵阳市第一人民医院、黔南州人民医院消化内科收治的溃疡性结肠炎患者共168例,采用随机分组法,将其分为3组。对照组57例,给予西医常规治疗;安慰剂组48例;实验组63例,口服美沙拉嗪。4周为1个疗程,治疗1个疗程。治疗前后对3组患者血沉(erythrocyte sedimentation rate,ESR)、PLT、D-二聚体以及治疗后临床症状等情况进行比较。结果治疗后,对照组及实验组ESR均比治疗前显著降低(P<0.05),且实验组[(10.65±8.92)mm/h]显著优于对照组[(17.39±10.50)mm/h],差异均有统计学意义(P<0.05);治疗后,对照组及实验组患者PLT数目比治疗前显著降低,且实验组(275.28±28.95)×109/L显著优于对照组(310.62±28.90)×109/L,差异均有统计学意义(P<0.05);治疗后,对照组及实验组患者D-二聚体水平比治疗前显著下降,差异有统计学意义(P<0.05)。对照组与实验组便血、肠息肉、消瘦等临床症状治疗总有效率显著高于安慰剂组,且实验组总有效率高于对照组,差异均有统计学意义(P<0.05)。结论美沙拉嗪可显著降低患者血沉(ESR)水平、减少患者血小板(PLT)数量、降低患者D-二聚体水平,且对于患者便血、肠息肉、身体消瘦等不良特征有较好的改善作用,是治疗溃疡性结肠炎的高效药物。更多还原

【Abstract】 Objective To analyze and compare serum ESR,PLT,D-dimer and clinical symptoms of patients with ulcerative colitis by the method of multicenter,and explore the clinical curative effect of mesalazine on ulcerative colitis patients. Methods A total of 168 patients with ulcerative colitis were selected in three hospitals,which were divided into three groups with double blind method. 57 cases in control group treated with conventional western medicine treatment; 48 cases in placebo group; 63 cases in experimental group treated with oral mesalazine,The patients were treated for a course treatment of four weeks. The ESR,PLT,D-dimer before and after the treatment and clinical symptoms after treatment were compared in three groups. Results ESR levels of control group and experimental group after treatment were lower than those of before treatment,ESR level of experimental group( 10. 65 ± 8. 92) mm / h was better than that of control group( 17. 39 ± 10. 50) mm / h,and the difference was statistically significant( P < 0. 05);PLT levels of control group and experimental group after treatment were lower than those of before treatment,PLT level of experimental group( 275. 28 ±28. 95) × 109/ L was better than that of control group( 310. 62 ± 28. 90) × 109/ L,and the difference was statistically significant( P < 0. 05); D-dimer levels of control group and experimental group after treatment were lower than those of before treatment,and the difference was statistically significant( P < 0. 05). Total effective rate of hematochezia,intestinal polyp and angular in control group and experimental group was higher than that in placebo group,total effective rate in experimental group was higer than that in control group,and the difference was statistically significant( P < 0. 05).Conclusion The mesalazine can significantly reduce ESR,PLT,D-dimer levels,and improve symptoms of hematochezia,intestinal polyp and angular,which was an efficient drug in the treatment of ulcerative colitis.更多还原