【摘要】 目的通过多中心研究,探究辛伐他汀对脑动脉粥样硬化患者MMP-2、MMP-9和血脂的影响。方法选取长治医学院附属和济医院、长治医学院附属和平医院以及湘雅医学院附属医院神经内科收治的脑动脉粥样硬化患者140例,采用随机数字表法均分为2组。对照组(n=70)予常规治疗,口服非诺贝特;实验组(n=70)在常规药物治疗基础上,加服辛伐他汀,1个月为1个疗程。6个疗程结束后,比较2组患者治疗前后MMP-2、MMP-9、血脂、C反应蛋白及白介素-6的变化情况。结果治疗后,2组患者血清MMP-2、MMP-9均有所降低,但实验组显著低于对照组,差异有统计学意义(P<0.05);2组患者血脂水平较治疗前均有所改善,但实验组较对照组改善更明显,差异有统计学意义(P<0.05);2组患者CRP及IL-6均有所降低,但实验组较对照组降低显著,差异有统计学意义(P<0.05)。结论辛伐他汀可有效改善脑动脉粥样硬化患者血清MMP-2、MMP-9、血脂、CRP及IL-6水平,是治疗脑动脉粥样硬化的有效药物。更多还原

【Abstract】 Objective To explore the effect of simvastatin on MMP-2,MMP-9 and lipid levels in patients with cerebral atherosclerosis through the multicenter study. Methods 140 cases with cerebral atherosclerosis were collected from heji hospital affiliated to Changzhi medical college,Heping hospital affiliated to Changzhi medical college and affiliated hospital of Xiangya medical college and divided into two groups randomly with digital table.Control group(n = 70) were treated with conventional western medicine treatment,received oral fenofibrate 0. 1 g,three times a day,a month for a period of treatment; Experimental group(n = 70) were received oral simvastatin 40 mg once a day,on the basis of the routine drug treatment,a month for a period of treatment. after 6 courses of treatment,serum protease metal matrix-2(MMP-2),metal matrix protease-9(MMP-9),blood lipid,Creactive protein and interleukin-6 levels of patients between two groups were observed and compared. Results After treatment,serum MMP-2,MMP-9of patients in both two groups were decreased,and their levels in experimental group were significantly lower than control group,the differences were statistically significant(P < 0. 05); lipid levels of patients in both two groups were improved compared with before treatment,and experimental group improved significantly compared with control group,the difference was statistically significant(P < 0. 05); CRP and IL-6 levels of patients in both two groups were decreased compared with before treatment,and the experimental group were significantly lower than control group,the differences were statistically significant(P < 0. 05). Conclusion Simvastatin could effectively improve cerebral levels of serum MMP-2,MMP-9,blood lipid,CRP and IL-6 in patients with,atherosclerosis is an effective drug for the treatment of cerebral atherosclerosis.更多还原