【摘要】 目的探讨生长抑素联合乌司他丁治疗对重症急性胰腺炎患者腹内压的影响,为临床治疗提供参考。方法将南阳市中心医院2011年11月~2014年5月收治的120例重症急性胰腺炎患者随机分为观察组和对照组,每组60例,对照组给予生长抑素进行治疗,观察组给予生长抑素联合乌司他丁进行治疗,观察和比较2组患者的治疗效果及腹内压。结果观察组总有效率为95.00%,对照组总有效率为66.67%,2组间的比较差异有统计学意义(P<0.05);观察组出现2例不良反应,占3.33%,对照组出现20例不良反应,占33.3%;观察组患者腹内压为(4.33±2.23)mm Hg,对照组患者腹内压为(9.10±4.42)mm Hg,2组患者不良反应发生率及腹内压的比较差异有统计学意义(P<0.05)。结论生长抑素联合乌司他丁治疗重症急性胰腺炎效果显著,安全性高,不良反应少。更多还原

【Abstract】 Objective To explore the effect of somatostatin combined with ulinastatin on intra-abdominal pressure in patients with severe acute pancreatitis,and provide reference for clinical treatment. Methods 120 cases of severe acute pancreatitis patients admitted in nanyang central hospital from November 2011 to May 2014 were randomly divided into observation group and control group,60 cases in each group,control group received somatostatin treatment,observation group received somatostatin combined with ulinastatin,therapeutic effect and intra-abdominal pressure were compared between two groups. Results The total effective rate was 95. 00% in observation group,the total effective rate was 66. 67% in control group,the difference between two groups was statistically significant(P < 0. 05); observation group had two cases of adverse reactions,accounting for 3. 33%,control group had 20 cases of adverse reactions,accounting for 33. 3%; intra-abdominal pressure in observation group was(4. 33 ± 2. 23) mm Hg,intraabdominal pressure in control group was(9. 10 ± 4. 42) mm Hg,the incidence of adverse reactions and intra-abdominal pressure were statistically significant(P < 0. 05). Conclusion Somatostatin combined with ulinastatin in treatment of severe acute pancreatitis has significant effect,safety,with less adverse reactions.更多还原