【摘要】 目的探讨雷公藤多苷联合香丹注射液治疗小儿过敏性紫癜性肾炎(henoch schonlein purpura nephritis,HSPN)的疗效观察及凝血机制的影响。方法将本组76例小儿过敏性紫癜性肾炎患者按照随机数字表法将其随机分为对照组和观察组(n=38)。对照组给予香丹注射液治疗,治疗组在对照组治疗基础上服用雷公藤多苷。2组治疗均以12周为一个疗程。结果治疗组治疗后总有效率(94.74%)显著高于对照组(68.42%),且具有显著性差异(P<0.05);2组治疗前凝血酶原时间(prothrombin time,PT)、纤维蛋白原(fibrinogen,FIB)、活化部分凝血活酶时间(activated partial thromboplastin time,APPT)、血小板(blood platelet,PLT)水平比较无显著性差异;对照组治疗后FIB、PLT水平显著低于治疗前(P<0.05),治疗前后PT、APPT不存在统计学显著性差异;治疗组治疗后FIB、PLT水平显著低于治疗前(P<0.05),治疗后较治疗前PT水平显著升高(P<0.05),APPT水平治疗前后无差异。治疗后治疗组PT水平显著高于对照组(P<0.05),治疗组PLT水平显著低于对照组(P<0.05),在FIB、APPT水平上2组不存在统计学差异。2组患者治疗后均未出现明显不良反应。结论雷公藤多苷联合香丹注射液治疗小儿过敏性紫癜性肾炎疗效显著,影响患儿凝血机制,改善PT、FIB、PLT水平,安全可靠。更多还原

【Abstract】 Objective To observe effects of tripterygium glycosides combined with Xiangdan injection in henoch schonlein purpura nephritis(HSPN) and influence of the clotting mechanism,providing reference for clinical diagnosis and treatment Methods 76 cases of children with allergic purpura nephritis were randomly divided into control group(n =38)and observation group(n = 38) according to the random number table.Control group was given Xiangdan injection treatment.Observation group was given Xiangdan injection treatment combined with tripterygium glycoside.12 weeks was considered as a course of treatment Results After treatment,the total efficiency rate in treatment group(94.74%)was significandy higher than control group(68.42%),which was statistically different(P < 0.05).Before treatment,prothrombin time(PT),fibrinogen(FIB),activated partial thromboplastin time(APPT),platelet(PLT) levels were not significantly different between two groups;FIB and PLT levels in the control group were significantly lower than before treatment(P <0.05),PT and APPT had no statistically significant difference before and after treatment After treatment in observation group,FIB and PLT levels were significandy lower than before treatment(P<0.05),PT level was significandy higher compared with before treatment(P<0.05),APTT level had no difference before and after treatment After treatment,PT in treatment group was significantly higher than the control group(P < 0.05),PLT in treatment group were significantly lower than the control group(P < 0.05),FIB and APTT had no statistical difference.There was no adverse reaction in two groups after treatment.Conclusion Tripterygium glycosides combined with Xiangdan injection treatment for HSPN has significant effect,which affect the children clotting mechanism to improve the PT,FIB,PLT levels.It is safe and valuable in clinical research.更多还原