The aging of adult stem cells has been researched by the traditional theories and methods of the aging of somatic cells and the unique role of the self-renew and the stem genes of adult stem cells has been ignored by now in the aging of adult stem cells. The down-regulation of stem genes may be the major cause of the aging of stem cells. By analysis of the relevant information, we found that the expression levels of the stem genes and aging-related genes are associated with mutual antagonism which can be re...
【基金】
国家自然科学基金资助项目(U1032003)~~
【更新日期】
2014-09-19
【分类号】
R346
【正文快照】
间充质干细胞作为理想的种子细胞用于衰老和病变引起的组织器官损伤修复,但间充质干细胞难于一次性大量获得,需要在体外进行扩增.体外培养的间充质干细胞随着传代次数的增加逐渐呈现衰老(aging or senescence)细胞的特征,不仅有胞体增大、扁平和胞浆内空泡等细胞形态学变化,还?
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