【摘要】 目的观察头颈部鳞状细胞癌组织中有丝分裂阻滞缺陷蛋白2(MAD2)的表达变化。方法头颈部鳞状细胞癌患者101例,分别取其肿瘤组织、肿瘤旁肌肉组织;以49例份正常头颈部肌肉组织作对照。采用免疫组化SP法检测上述组织标本中的MAD2。结果肿瘤组织、肿瘤旁肌肉组织、正常头颈部肌肉组织中MAD2的阳性表达率分别为90.1%、53.5%、46.9%;前者与后两者相比,P均<0.05。有、无淋巴结转移的头颈部鳞状细胞癌患者肿瘤组织中MAD2阳性表达率分别为96.6%、81.4%,两者相比,P<0.05。结论头颈部鳞状细胞癌组织中MAD2阳性表达率升高,其异常高表达可能参与了头颈部鳞状细胞癌的发生发展过程。更多还原

【Abstract】 Objective To study the expression of mitotic arrest deficient-2( MAD2) in squamous cell carcinoma( HNSCC) tissues from head and neck. Methods The MAD2 in 101 HNSCCs tissues and tumor adjacent tissues from 101 patients with HNSCC head and neck,neck muscles from 49 human normal were observed using immunohistochemistry. Results The positive expression rates of MAD2 in tumor tissues,para-carcinoma muscular tissues and normal head and neckmuscles were 90. 1%,53. 5% and 46. 9% respectively; there were significant differences between the former and the latter two( P < 0. 05). The positive rate of MAD2 in HNSCC tissues with / without local lymph node metastasis was 98. 3% and81. 4%( P < 0. 05). Conclusion The positive expression rate of MAD2 has increased in HNSCC tissues. MAD2 may play an important role in the initiation and development of HNSCC.更多还原