【摘要】 目的探讨妊娠期糖尿病(GDM)对新生儿脐动脉血清抵抗素与胰岛素抵抗的影响。方法对33例GDM母亲分娩的新生儿(观察组)及30例无糖尿病母亲分娩的足月新生儿(对照组)脐血血清抵抗素、血糖(PG)、胰岛素进行测定,计算胰岛素抵抗指数(IRI)。分析新生儿脐血清抵抗素与PG、胰岛素及IRI的相关性。结果观察组PG、胰岛素和IRI均明显高于对照组,抵抗素水平低于对照组(P均<0.05)。观察组新生儿脐血血清抵抗素与PG、IRI呈正相关(r分别为0.43、0.56,P均<0.05),与胰岛素水平无关(P>0.05)。结论糖尿病母亲分娩的新生儿存在胰岛素抵抗,抵抗素可能参与了胰岛素抵抗的病理过程。更多还原

【Abstract】 Objective To investigate the effects of gestational diabetes mellitus( GDM) on umbilical artery serum resistin and insulin resistance( IR) in infants. Methods The concentrations of resistin,plasma glucose( PG),insulin( INS) and the insulin resistance index( IRI) of the umbilical cord serum were separately examined in 33 infants of GDM mothers( observation group) and 30 normal control subjects( control group). The correlations between serum resistin and PG,INS and IRI were analyzed. Results The umbilical artery serum levels of PG,INS and IRI in the observation group were significantly higher than those of the control group( all P < 0. 01),but resistin level was significantly decreased as compared with that of the control group( P < 0. 01). Correlation analysis showed that resistin was positively correlated with PG and IRI( r = 0. 43,r = 0. 56; all P < 0. 01),and no correlation was found between resistin and insulin( r = 0. 18,P> 0. 05). Conclusions The infants who were born by GDM mothers have insulin resistance,and resistin may play a role in the pathogenesis of insulin resistance.更多还原