【摘要】 目的探讨静脉输注人免疫球蛋白G(IgG)对慢性不可预料应激抑郁模型大鼠海马功能的影响。方法对慢性不可预料应激抑郁模型大鼠分别给予静脉输注人IgG+应激(IgG组)和单纯应激(CUS组)处理,对照组不行任何处理。分别采用悬尾实验、糖水偏好实验、强迫游泳实验、自主活动实验和5-溴脱氧尿嘧啶核苷(BrdU)标记海马齿状回神经元,检测神经元再生情况。结果 IgG组及对照组糖水偏好消耗显著大于CUS组(P均<0.01);悬尾实验、强迫游泳实验和自主活动实验不动时间IgG组及对照组显著小于CUS组(P均<0.01);IgG组海马区域BrdU阳性细胞数与CUS组比较有统计学差异(P<0.01)。结论静脉输注人IgG对慢性不可预料应激造成的大鼠抑郁样行为具有改善作用;可保护海马的神经元再生功能。更多还原

【Abstract】 Objective To investigate the effect of intravenous human immunoglobulin G( IgG) on depressive model rats subjected to chronic unpredictable stress. Methods Depressive model rats subjected to chronic unpredictable stress were randomly divided into 3 groups: intravenous immunoglobulin G( IVIG) + stress group( IVIG group),stress-only group( CUS group) and the control group without any treatment. Tail suspension test,sucrose preference test,forces swimming test,locomotor activity and BrdU labeling neuron of hippocampal dentate gyrus based neurogenesis were used to analyze the effect of IVIG on depressive model rats. Results Sucrose consumption in the IVIG group and control group was significantly less than that of the CUS group( P < 0. 01),while duration of immobility of tail suspension test,forced swimming test and locomotor activity was significantly shorter than that of the CUS group( all P < 0. 01). The difference of BrdU positive cell number in the hippocampus between the two groups was significant( P < 0. 01). Conclusion IVIG can improve the depression-like behaviors of rats subjected to chronic unpredictable stress and protect the functions of hippocampal neurons.更多还原