【摘要】 目的研究奥扎格雷钠对患者血小板膜GPⅡb/Ⅲa复合物和P-选择素、NIHSS评分的影响,探讨奥扎格雷钠对血小板活化的影响及与临床疗效的关系。方法对脑梗死急性期患者入院第1天和第14天进行NIHSS评分,并应用流式细胞术检测血小板膜GPⅡb/Ⅲa复合物和P-选择素。将患者分为阿司匹林组、奥扎格雷钠组,对比两组患者NIHSS评分和血小板膜GPⅡb/Ⅲa复合物和P-选择素的差异。结果两组治疗第14天奥扎格雷钠组的血小板膜NIHSS、GPⅡb/Ⅲa复合物和P-选择素均比阿司匹林组下降更明显(P<0.05)。结论阿司匹林和奥扎格雷钠均可降低血小板活化程度,从而缓解脑梗死病情,而奥扎格雷钠作用更强,取得的临床疗效更为明显。更多还原

【Abstract】 Objective To study the effects of sodium ozagrel on platelet membrane glycoprotein Ⅱb /Ⅲa complex and P- selectin,NIHSS. To reveal the effects of sodium ozagrel on platelet activation and their correlations to clinical treatment efficacy. Methods Patients with acute cerebral infarction were evaluated with NIHSS on the 1 st and the 14 th days after admission. Detect platelet membrane glycoprotein Ⅱb / Ⅲa complex and P- selectin in patients. Patients with acute cerebral infarction were randomly assigned to aspirin group and sodium ozagrel group. compared the difference of NIHSS,platelet membrane glycoprotein Ⅱb / Ⅲa complex and P- selectin between two groups. Results After therapy for 14 days,the NIHSS,platelet membrane glycoprotein Ⅱb / Ⅲa complex and P- selectin of patients with acute cerebral infarction therapy with sodium ozagrel was lower than those therapy by aspirin( P < 0. 05). Conclusion Both aspirin and sodium ozagrel can reduce the lever of platelet activation and release the disease of cerebral infarction. Sodium ozagrel treatment was especially effective.更多还原