【摘要】 目的:观察泻南补北法代表方黄连阿胶汤治疗非系统受累干燥综合征(NSI-SS)的疗效。方法:选取2011年4月~2013年4月在我院中西医结合风湿免疫科门诊及病房治疗的23例NSI-SS,随机分为中药治疗组和硫酸羟基氯喹对照组。中药治疗组服用黄连阿胶汤水煎剂,每日1剂,早中晚分次温服。对照组服用硫酸羟基氯喹,100mg/次,每天2次口服。两组均连续用药3个月(12周)。观察两组患者治疗前后不同时间的临床症状和体征评分,唾液流量、Schirmer试验及γ-球蛋白测定。结果:临床症状和体征评分:两组治疗前后均有统计学差异,治疗后两组间比较亦有统计学差异(P<0.05)。唾液流量:两组用药8周后唾液流量增加有统计学差异,在治疗4周后两组间比较差异有统计学差异(P<0.05);Schirmer试验:两组用药8周后泪液增加有统计学差异,在治疗8周时两组间比较差异有统计学差异(P<0.05);γ-球蛋白含量:对照组治疗前后比较降低有统计学差异(P<0.05),中药组治疗前后无统计学差异(P>0.05)。结论:黄连阿胶汤治疗NSI-SS起效时间在治疗4~8周,在临床症状、体征、唾液流量、泪液流量的改善上优于硫酸羟基氯喹。更多还原

【Abstract】 Objective: To observe the effect of Huanglian Ejiao Decoction that was the representative prescription of Xienan Bubei Method to treat non-systemic involved sjogren’s syndrome( NSI-SS). Methods: Selecting April 2011 ~ April 2013 in our hospital outpatient and ward rheumatism lead of the treatment of 23 cases of NSI-SS,were randomly divided into Chinese medicine treatment group and hydroxychloroquine sulfate controlled group. TCM treatment group took Huanglian Ejiao Decoction, daily 1 agent. The controlled group took hydroxychloroquine sulfate 100mg / times,2 times a day. Both groups took continuous medication for 3 months( 12 weeks). Observing before and after treatment in both groups at different times and comparing the signs and symptoms score,saliva flow,Schirmer test and serum γ-globulin. Results: The clinical symptoms and signs scores: before and after treatment of the two groups were statistically significant. Between the two groups after treatment was also statistically significant( P < 0. 05). Saliva flow: after 8 weeks,saliva flow of two groups increased statistically significant,in the treatment of 4 weeks after the comparison between the two groups statistically significant differences( P <0. 05); Schirmer test: after 8 weeks,tear of two groups increased statistically significant. In the treatment of 8 weeks when two to form a comparative differences statistically significant( P < 0. 05); serum γ- globulin: before and after treatment of the controlled group reduced statistically significant( P <0. 05),no statistical differences before and after TCM group( P >0. 05). Conclusion: The effect initiating time of Huanglian Ejiao Decoction is being about in the treatment of 4 to 8 weeks. It’s better than hydroxychloroquine sulfate on the improvement of the clinical symptoms,signs,saliva,tears flow.更多还原